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Biosynthesis of the RiPP trojan horse nucleotide antibiotic microcin C is directed by the N-formyl of the peptide precursor

Microcin C7 (McC) is a peptide antibiotic modified by a linkage of the terminal isoAsn amide to AMP via a phosphoramidate bond. Post-translational modification on this ribosomally produced heptapeptide precursor is carried out by MccB, which consumes two equivalents of ATP to generate the N–P linkag...

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Detalles Bibliográficos
Autores principales:	Dong, Shi-Hui, Kulikovsky, Alexey, Zukher, Inna, Estrada, Paola, Dubiley, Svetlana, Severinov, Konstantin, Nair, Satish K.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385645/ https://www.ncbi.nlm.nih.gov/pubmed/30881667 http://dx.doi.org/10.1039/c8sc03173h

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