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Modeling and simulation of the endogenous CYP3A induction marker 4β-hydroxycholesterol during enasidenib treatment

BACKGROUND: Enasidenib (IDHIFA(®), AG-221) is a first-in-class, targeted inhibitor of mutant IDH2 proteins for treatment of relapsed or refractory acute myeloid leukemia. This was a Phase I/II study evaluating safety, efficacy, and pharmacokinetics/pharmacodynamics (PK/PD) of orally administered ena...

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Detalles Bibliográficos
Autores principales:	Li, Yan, Connarn, Jamie N, Chen, Jian, Tong, Zeen, Palmisano, Maria, Zhou, Simon
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385784/ https://www.ncbi.nlm.nih.gov/pubmed/30858735 http://dx.doi.org/10.2147/CPAA.S192687

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