Intramolecular asymmetric reductive amination: synthesis of enantioenriched dibenz[c,e]azepines

An Ir-catalyzed intramolecular asymmetric reductive amination (ARA) of bridged biaryl derivatives has been described. Using this unprecedented approach, synthetically useful dibenz[c,e]azepines containing both central and axial chiralities are obtained with excellent enantiocontrol (up to 97% ee). T...

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Detalles Bibliográficos
Autores principales: Yang, Tao, Guo, Xiaochong, Yin, Qin, Zhang, Xumu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385856/
https://www.ncbi.nlm.nih.gov/pubmed/30881676
http://dx.doi.org/10.1039/c8sc04482a

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385856/
https://www.ncbi.nlm.nih.gov/pubmed/30881676
http://dx.doi.org/10.1039/c8sc04482a

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