Sense and antisense RNA are not toxic in Drosophila models of C9orf72-associated ALS/FTD

A GGGGCC hexanucleotide repeat expansion in the C9orf72 gene is the most common genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Neurodegeneration may occur via transcription of the repeats into inherently toxic repetitive sense and antisense RNA species, or via repeat-ass...

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Detalles Bibliográficos
Autores principales: Moens, Thomas G., Mizielinska, Sarah, Niccoli, Teresa, Mitchell, Jamie S., Thoeng, Annora, Ridler, Charlotte E., Grönke, Sebastian, Esser, Jacqueline, Heslegrave, Amanda, Zetterberg, Henrik, Partridge, Linda, Isaacs, Adrian M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2018
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385858/
https://www.ncbi.nlm.nih.gov/pubmed/29380049
http://dx.doi.org/10.1007/s00401-017-1798-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6385858/
https://www.ncbi.nlm.nih.gov/pubmed/29380049
http://dx.doi.org/10.1007/s00401-017-1798-3

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