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Larotrectinib in adult patients with solid tumours: a multi-centre, open-label, phase I dose-escalation study

BACKGROUND: NTRK1, NTRK2 and NTRK3 gene fusions (NTRK gene fusions) occur in a range of adult cancers. Larotrectinib is a potent and highly selective ATP-competitive inhibitor of TRK kinases and has demonstrated activity in patients with tumours harbouring NTRK gene fusions. PATIENTS AND METHODS: Th...

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Detalles Bibliográficos
Autores principales:	Hong, D S, Bauer, T M, Lee, J J, Dowlati, A, Brose, M S, Farago, A F, Taylor, M, Shaw, A T, Montez, S, Meric-Bernstam, F, Smith, S, Tuch, B B, Ebata, K, Cruickshank, S, Cox, M C, Burris, H A, Doebele, R C
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386027/ https://www.ncbi.nlm.nih.gov/pubmed/30624546 http://dx.doi.org/10.1093/annonc/mdy539

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