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Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017
Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, the national surveillance of bloodstream infections (BSI) due to CPE (Klebsiella pneumoniae and Escherichia coli) was instituted in 2013. All CPE-BSI cases reported to the surveillance in the...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386214/ https://www.ncbi.nlm.nih.gov/pubmed/30722813 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800159 |
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author | Iacchini, Simone Sabbatucci, Michela Gagliotti, Carlo Rossolini, Gian Maria Moro, Maria Luisa Iannazzo, Stefania D’Ancona, Fortunato Pezzotti, Patrizio Pantosti, Annalisa |
author_facet | Iacchini, Simone Sabbatucci, Michela Gagliotti, Carlo Rossolini, Gian Maria Moro, Maria Luisa Iannazzo, Stefania D’Ancona, Fortunato Pezzotti, Patrizio Pantosti, Annalisa |
author_sort | Iacchini, Simone |
collection | PubMed |
description | Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, the national surveillance of bloodstream infections (BSI) due to CPE (Klebsiella pneumoniae and Escherichia coli) was instituted in 2013. All CPE-BSI cases reported to the surveillance in the years 2014–17 were analysed in order to investigate incidence rate (IR), trend, main individual characteristics and enzymes involved in CPE resistance. Throughout this period, 7,632 CPE-BSI cases (IR: 3.14/100,000 inhabitants) were reported from all 21 regions and autonomous provinces in Italy, with an increasing number of reported cases (2014: 1,403; 2015: 1,838; 2016: 2,183; 2017: 2,208). CPE-BSI cases mainly occurred in subjects aged over 60 years (70.9%) and more frequently in males (62.7%) than in females. Most of the cases originated in hospitals (87.2%), mainly in intensive care units (38.0%), and were associated with central or peripheral venous catheter use (23.9%) or with urinary tract infections (21.1%). Almost all CPE-BSI (98.1%) were due to K. pneumoniae carrying the K. pneumoniae carbapenemase (KPC) enzyme (95.2%). These data show that carbapenemase-producing K. pneumoniae are endemic in our country, causing a high number of BSI and representing a threat to patient safety. |
format | Online Article Text |
id | pubmed-6386214 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-63862142019-03-01 Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 Iacchini, Simone Sabbatucci, Michela Gagliotti, Carlo Rossolini, Gian Maria Moro, Maria Luisa Iannazzo, Stefania D’Ancona, Fortunato Pezzotti, Patrizio Pantosti, Annalisa Euro Surveill Surveillance Following the rapid increase of infections due to carbapenemase-producing Enterobacteriaceae (CPE) in Italy, the national surveillance of bloodstream infections (BSI) due to CPE (Klebsiella pneumoniae and Escherichia coli) was instituted in 2013. All CPE-BSI cases reported to the surveillance in the years 2014–17 were analysed in order to investigate incidence rate (IR), trend, main individual characteristics and enzymes involved in CPE resistance. Throughout this period, 7,632 CPE-BSI cases (IR: 3.14/100,000 inhabitants) were reported from all 21 regions and autonomous provinces in Italy, with an increasing number of reported cases (2014: 1,403; 2015: 1,838; 2016: 2,183; 2017: 2,208). CPE-BSI cases mainly occurred in subjects aged over 60 years (70.9%) and more frequently in males (62.7%) than in females. Most of the cases originated in hospitals (87.2%), mainly in intensive care units (38.0%), and were associated with central or peripheral venous catheter use (23.9%) or with urinary tract infections (21.1%). Almost all CPE-BSI (98.1%) were due to K. pneumoniae carrying the K. pneumoniae carbapenemase (KPC) enzyme (95.2%). These data show that carbapenemase-producing K. pneumoniae are endemic in our country, causing a high number of BSI and representing a threat to patient safety. European Centre for Disease Prevention and Control (ECDC) 2019-01-31 /pmc/articles/PMC6386214/ /pubmed/30722813 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800159 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Surveillance Iacchini, Simone Sabbatucci, Michela Gagliotti, Carlo Rossolini, Gian Maria Moro, Maria Luisa Iannazzo, Stefania D’Ancona, Fortunato Pezzotti, Patrizio Pantosti, Annalisa Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 |
title | Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 |
title_full | Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 |
title_fullStr | Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 |
title_full_unstemmed | Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 |
title_short | Bloodstream infections due to carbapenemase-producing Enterobacteriaceae in Italy: results from nationwide surveillance, 2014 to 2017 |
title_sort | bloodstream infections due to carbapenemase-producing enterobacteriaceae in italy: results from nationwide surveillance, 2014 to 2017 |
topic | Surveillance |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386214/ https://www.ncbi.nlm.nih.gov/pubmed/30722813 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800159 |
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