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Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks
BACKGROUND: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma tic...
Autores principales: | , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
European Centre for Disease Prevention and Control (ECDC)
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386216/ https://www.ncbi.nlm.nih.gov/pubmed/30722811 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800093 |
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author | Bartolini, Barbara Gruber, Cesare EM Koopmans, Marion Avšič, Tatjana Bino, Sylvia Christova, Iva Grunow, Roland Hewson, Roger Korukluoglu, Gulay Lemos, Cinthia Menel Mirazimi, Ali Papa, Anna Sanchez-Seco, Maria Paz Sauer, Aisha V. Zeller, Hervè Nisii, Carla Capobianchi, Maria Rosaria Ippolito, Giuseppe Reusken, Chantal B. Di Caro, Antonino |
author_facet | Bartolini, Barbara Gruber, Cesare EM Koopmans, Marion Avšič, Tatjana Bino, Sylvia Christova, Iva Grunow, Roland Hewson, Roger Korukluoglu, Gulay Lemos, Cinthia Menel Mirazimi, Ali Papa, Anna Sanchez-Seco, Maria Paz Sauer, Aisha V. Zeller, Hervè Nisii, Carla Capobianchi, Maria Rosaria Ippolito, Giuseppe Reusken, Chantal B. Di Caro, Antonino |
author_sort | Bartolini, Barbara |
collection | PubMed |
description | BACKGROUND: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. AIMS: To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. METHODS: We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVD-LabNet (Emerging Viral Diseases-Expert Laboratory Network). RESULTS: Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. CONCLUSION: No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses. |
format | Online Article Text |
id | pubmed-6386216 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | European Centre for Disease Prevention and Control (ECDC) |
record_format | MEDLINE/PubMed |
spelling | pubmed-63862162019-03-01 Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks Bartolini, Barbara Gruber, Cesare EM Koopmans, Marion Avšič, Tatjana Bino, Sylvia Christova, Iva Grunow, Roland Hewson, Roger Korukluoglu, Gulay Lemos, Cinthia Menel Mirazimi, Ali Papa, Anna Sanchez-Seco, Maria Paz Sauer, Aisha V. Zeller, Hervè Nisii, Carla Capobianchi, Maria Rosaria Ippolito, Giuseppe Reusken, Chantal B. Di Caro, Antonino Euro Surveill Review BACKGROUND: Crimean-Congo haemorrhagic fever virus (CCHFV) is considered an emerging infectious disease threat in the European Union. Since 2000, the incidence and geographic range of confirmed CCHF cases have markedly increased, following changes in the distribution of its main vector, Hyalomma ticks. AIMS: To review scientific literature and collect experts’ opinion to analyse relevant aspects of the laboratory management of human CCHF cases and any exposed contacts, as well as identify areas for advancement of international collaborative preparedness and laboratory response plans. METHODS: We conducted a literature review on CCHF molecular diagnostics through an online search. Further, we obtained expert opinions on the key laboratory aspects of CCHF diagnosis. Consulted experts were members of two European projects, EMERGE (Efficient response to highly dangerous and emerging pathogens at EU level) and EVD-LabNet (Emerging Viral Diseases-Expert Laboratory Network). RESULTS: Consensus was reached on relevant and controversial aspects of CCHF disease with implications for laboratory management of human CCHF cases, including biosafety, diagnostic algorithm and advice to improve lab capabilities. Knowledge on the diffusion of CCHF can be obtained by promoting syndromic approach to infectious diseases diagnosis and by including CCHFV infection in the diagnostic algorithm of severe fevers of unknown origin. CONCLUSION: No effective vaccine and/or therapeutics are available at present so outbreak response relies on rapid identification and appropriate infection control measures. Frontline hospitals and reference laboratories have a crucial role in the response to a CCHF outbreak, which should integrate laboratory, clinical and public health responses. European Centre for Disease Prevention and Control (ECDC) 2019-01-31 /pmc/articles/PMC6386216/ /pubmed/30722811 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800093 Text en This article is copyright of the authors or their affiliated institutions, 2019. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made. |
spellingShingle | Review Bartolini, Barbara Gruber, Cesare EM Koopmans, Marion Avšič, Tatjana Bino, Sylvia Christova, Iva Grunow, Roland Hewson, Roger Korukluoglu, Gulay Lemos, Cinthia Menel Mirazimi, Ali Papa, Anna Sanchez-Seco, Maria Paz Sauer, Aisha V. Zeller, Hervè Nisii, Carla Capobianchi, Maria Rosaria Ippolito, Giuseppe Reusken, Chantal B. Di Caro, Antonino Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks |
title | Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks |
title_full | Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks |
title_fullStr | Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks |
title_full_unstemmed | Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks |
title_short | Laboratory management of Crimean-Congo haemorrhagic fever virus infections: perspectives from two European networks |
title_sort | laboratory management of crimean-congo haemorrhagic fever virus infections: perspectives from two european networks |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386216/ https://www.ncbi.nlm.nih.gov/pubmed/30722811 http://dx.doi.org/10.2807/1560-7917.ES.2019.24.5.1800093 |
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