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Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis

Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain agi...

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Autores principales: Bang, EunJin, Lee, Bonggi, Noh, Sang-Gyun, Kim, Dae Hyun, Jung, Hee Jin, Ha, Sugyeong, Yu, Byung Pal, Chung, Hae Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society for Biochemistry and Molecular Biology 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386225/
https://www.ncbi.nlm.nih.gov/pubmed/30545444
http://dx.doi.org/10.5483/BMBRep.2019.52.1.301
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author Bang, EunJin
Lee, Bonggi
Noh, Sang-Gyun
Kim, Dae Hyun
Jung, Hee Jin
Ha, Sugyeong
Yu, Byung Pal
Chung, Hae Young
author_facet Bang, EunJin
Lee, Bonggi
Noh, Sang-Gyun
Kim, Dae Hyun
Jung, Hee Jin
Ha, Sugyeong
Yu, Byung Pal
Chung, Hae Young
author_sort Bang, EunJin
collection PubMed
description Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity.
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spelling pubmed-63862252019-03-04 Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis Bang, EunJin Lee, Bonggi Noh, Sang-Gyun Kim, Dae Hyun Jung, Hee Jin Ha, Sugyeong Yu, Byung Pal Chung, Hae Young BMB Rep Invited Mini Review Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity. Korean Society for Biochemistry and Molecular Biology 2019-01 2019-01-31 /pmc/articles/PMC6386225/ /pubmed/30545444 http://dx.doi.org/10.5483/BMBRep.2019.52.1.301 Text en Copyright © 2019 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Invited Mini Review
Bang, EunJin
Lee, Bonggi
Noh, Sang-Gyun
Kim, Dae Hyun
Jung, Hee Jin
Ha, Sugyeong
Yu, Byung Pal
Chung, Hae Young
Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
title Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
title_full Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
title_fullStr Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
title_full_unstemmed Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
title_short Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
title_sort modulation of senoinflammation by calorie restriction based on biochemical and omics big data analysis
topic Invited Mini Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386225/
https://www.ncbi.nlm.nih.gov/pubmed/30545444
http://dx.doi.org/10.5483/BMBRep.2019.52.1.301
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