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Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis
Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain agi...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Society for Biochemistry and Molecular Biology
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386225/ https://www.ncbi.nlm.nih.gov/pubmed/30545444 http://dx.doi.org/10.5483/BMBRep.2019.52.1.301 |
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author | Bang, EunJin Lee, Bonggi Noh, Sang-Gyun Kim, Dae Hyun Jung, Hee Jin Ha, Sugyeong Yu, Byung Pal Chung, Hae Young |
author_facet | Bang, EunJin Lee, Bonggi Noh, Sang-Gyun Kim, Dae Hyun Jung, Hee Jin Ha, Sugyeong Yu, Byung Pal Chung, Hae Young |
author_sort | Bang, EunJin |
collection | PubMed |
description | Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity. |
format | Online Article Text |
id | pubmed-6386225 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Korean Society for Biochemistry and Molecular Biology |
record_format | MEDLINE/PubMed |
spelling | pubmed-63862252019-03-04 Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis Bang, EunJin Lee, Bonggi Noh, Sang-Gyun Kim, Dae Hyun Jung, Hee Jin Ha, Sugyeong Yu, Byung Pal Chung, Hae Young BMB Rep Invited Mini Review Aging is a complex and progressive process characterized by physiological and functional decline with time that increases susceptibility to diseases. Aged-related functional change is accompanied by a low-grade, unresolved chronic inflammation as a major underlying mechanism. In order to explain aging in the context of chronic inflammation, a new integrative concept on age-related chronic inflammation is necessary that encompasses much broader and wider characteristics of cells, tissues, organs, systems, and interactions between immune and non-immune cells, metabolic and non-metabolic organs. We have previously proposed a novel concept of senescent (seno)-inflammation and provided its frameworks. This review summarizes senoinflammation concept and additionally elaborates modulation of senoinflammation by calorie restriction (CR). Based on aging and CR studies and systems-biological analysis of Omics big data, we observed that senescence associated secretory phenotype (SASP) primarily composed of cytokines and chemokines was notably upregulated during aging whereas CR suppressed them. This result further strengthens the novel concept of senoinflammation in aging process. Collectively, such evidence of senoinflammation and modulatory role of CR provide insights into aging mechanism and potential interventions, thereby promoting healthy longevity. Korean Society for Biochemistry and Molecular Biology 2019-01 2019-01-31 /pmc/articles/PMC6386225/ /pubmed/30545444 http://dx.doi.org/10.5483/BMBRep.2019.52.1.301 Text en Copyright © 2019 by the The Korean Society for Biochemistry and Molecular Biology This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Invited Mini Review Bang, EunJin Lee, Bonggi Noh, Sang-Gyun Kim, Dae Hyun Jung, Hee Jin Ha, Sugyeong Yu, Byung Pal Chung, Hae Young Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis |
title | Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis |
title_full | Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis |
title_fullStr | Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis |
title_full_unstemmed | Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis |
title_short | Modulation of senoinflammation by calorie restriction based on biochemical and Omics big data analysis |
title_sort | modulation of senoinflammation by calorie restriction based on biochemical and omics big data analysis |
topic | Invited Mini Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386225/ https://www.ncbi.nlm.nih.gov/pubmed/30545444 http://dx.doi.org/10.5483/BMBRep.2019.52.1.301 |
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