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New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement

BACKGROUND AND AIMS: Various studies have been previously conducted on the diagnosis of lymphadenopathy as benign or malignant, but the results vary. These studies did not describe the inter-rater agreement on the EUS features of lymphadenopathy. In this study, we evaluate the inter-rater agreement...

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Autores principales: Takasaki, Yusuke, Irisawa, Atsushi, Shibukawa, Goro, Sato, Ai, Abe, Yoko, Yamabe, Akane, Arakawa, Noriyuki, Maki, Takumi, Yoshida, Yoshitsugu, Igarashi, Ryo, Yamamoto, Shogo, Ikeda, Tsunehiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386303/
https://www.ncbi.nlm.nih.gov/pubmed/30794598
http://dx.doi.org/10.1371/journal.pone.0212427
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author Takasaki, Yusuke
Irisawa, Atsushi
Shibukawa, Goro
Sato, Ai
Abe, Yoko
Yamabe, Akane
Arakawa, Noriyuki
Maki, Takumi
Yoshida, Yoshitsugu
Igarashi, Ryo
Yamamoto, Shogo
Ikeda, Tsunehiko
author_facet Takasaki, Yusuke
Irisawa, Atsushi
Shibukawa, Goro
Sato, Ai
Abe, Yoko
Yamabe, Akane
Arakawa, Noriyuki
Maki, Takumi
Yoshida, Yoshitsugu
Igarashi, Ryo
Yamamoto, Shogo
Ikeda, Tsunehiko
author_sort Takasaki, Yusuke
collection PubMed
description BACKGROUND AND AIMS: Various studies have been previously conducted on the diagnosis of lymphadenopathy as benign or malignant, but the results vary. These studies did not describe the inter-rater agreement on the EUS features of lymphadenopathy. In this study, we evaluate the inter-rater agreement on EUS features and propose EUS diagnostic norms for lymphadenopathy based on inter-rater agreement. METHOD: A total of 68 lymph nodes subjected to EUS-fine needle aspiration (FNA) were reviewed by five endoscopic experts. The EUS features evaluated lymph node size, shape, border, margin, echogenicity, homogeneity, and the hilum of the lymph node. Inter-rater agreement (multi-rater kappa statics) was performed. We established new criteria using results with a high degree of inter-rater agreement from EUS features and compared them with the former criteria. RESULT: There was a moderate agreement on shape, kappa (K) = 0.44 (95% confidence interval [CI]: 0.34–0.54), and fair agreement on echogenicity, homogeneity, border, and hilum of the lymph node, K (95% CI) = 0.33 (0.17–0.38), 0.34 (0.26–0.35), 0.22 (0.21–0.31), and 0.22 (0.11–0.26), respectively. This resulted in the establishment of new EUS diagnostic criteria using shape, long axis > 20 mm and short axis > 10 mm. New criteria were superior to old criteria (area under the curve 0.82 vs 0.52, P < 0.001). CONCLUSION: EUS diagnostic criteria for lymphadenopathy based on inter-rater agreement were more accurate than old criteria. This result will be useful for the diagnosis of lymphadenopathy.
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spelling pubmed-63863032019-03-09 New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement Takasaki, Yusuke Irisawa, Atsushi Shibukawa, Goro Sato, Ai Abe, Yoko Yamabe, Akane Arakawa, Noriyuki Maki, Takumi Yoshida, Yoshitsugu Igarashi, Ryo Yamamoto, Shogo Ikeda, Tsunehiko PLoS One Research Article BACKGROUND AND AIMS: Various studies have been previously conducted on the diagnosis of lymphadenopathy as benign or malignant, but the results vary. These studies did not describe the inter-rater agreement on the EUS features of lymphadenopathy. In this study, we evaluate the inter-rater agreement on EUS features and propose EUS diagnostic norms for lymphadenopathy based on inter-rater agreement. METHOD: A total of 68 lymph nodes subjected to EUS-fine needle aspiration (FNA) were reviewed by five endoscopic experts. The EUS features evaluated lymph node size, shape, border, margin, echogenicity, homogeneity, and the hilum of the lymph node. Inter-rater agreement (multi-rater kappa statics) was performed. We established new criteria using results with a high degree of inter-rater agreement from EUS features and compared them with the former criteria. RESULT: There was a moderate agreement on shape, kappa (K) = 0.44 (95% confidence interval [CI]: 0.34–0.54), and fair agreement on echogenicity, homogeneity, border, and hilum of the lymph node, K (95% CI) = 0.33 (0.17–0.38), 0.34 (0.26–0.35), 0.22 (0.21–0.31), and 0.22 (0.11–0.26), respectively. This resulted in the establishment of new EUS diagnostic criteria using shape, long axis > 20 mm and short axis > 10 mm. New criteria were superior to old criteria (area under the curve 0.82 vs 0.52, P < 0.001). CONCLUSION: EUS diagnostic criteria for lymphadenopathy based on inter-rater agreement were more accurate than old criteria. This result will be useful for the diagnosis of lymphadenopathy. Public Library of Science 2019-02-22 /pmc/articles/PMC6386303/ /pubmed/30794598 http://dx.doi.org/10.1371/journal.pone.0212427 Text en © 2019 Takasaki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Takasaki, Yusuke
Irisawa, Atsushi
Shibukawa, Goro
Sato, Ai
Abe, Yoko
Yamabe, Akane
Arakawa, Noriyuki
Maki, Takumi
Yoshida, Yoshitsugu
Igarashi, Ryo
Yamamoto, Shogo
Ikeda, Tsunehiko
New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
title New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
title_full New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
title_fullStr New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
title_full_unstemmed New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
title_short New endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
title_sort new endoscopic ultrasonography criteria for malignant lymphadenopathy based on inter-rater agreement
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386303/
https://www.ncbi.nlm.nih.gov/pubmed/30794598
http://dx.doi.org/10.1371/journal.pone.0212427
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