Cargando…

Mechanism and resistance for antimycobacterial activity of a fluoroquinophenoxazine compound

We have previously reported the inhibition of bacterial topoisomerase I activity by a fluoroquinophenoxazine compound (FP-11g) with a 6-bipiperidinyl lipophilic side chain that exhibited promising antituberculosis activity (MIC = 2.5 μM against Mycobacterium tuberculosis, SI = 9.8). Here, we found t...

Descripción completa

Detalles Bibliográficos
Autores principales: Garcia, Pamela K., Annamalai, Thirunavukkarasu, Wang, Wenjie, Bell, Raven S., Le, Duc, Martin Pancorbo, Paula, Sikandar, Sabah, Seddek, Ahmed, Yu, Xufen, Sun, Dianqing, Uhlemann, Anne-Catrin, Tiwari, Purushottam B., Leng, Fenfei, Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386362/
https://www.ncbi.nlm.nih.gov/pubmed/30794538
http://dx.doi.org/10.1371/journal.pone.0207733

Ejemplares similares