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The 14-3-3η chaperone protein promotes antiviral innate immunity via facilitating MDA5 oligomerization and intracellular redistribution

MDA5 belongs to the RIG-I-like receptor family and plays a non-redundant role in recognizing cytoplasmic viral RNA to induce the production of type I IFNs. Upon RNA ligand stimulation, we observed the redistribution of MDA5 from the cytosol to mitochondrial membrane fractions. However, the molecular...

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Detalles Bibliográficos
Autores principales:	Lin, Jhih-Pu, Fan, Yu-Kuan, Liu, Helene Minyi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2019
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386420/ https://www.ncbi.nlm.nih.gov/pubmed/30742689 http://dx.doi.org/10.1371/journal.ppat.1007582

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