Enhanced IL-1β production is mediated by a TLR2-MYD88-NLRP3 signaling axis during coinfection with influenza A virus and Streptococcus pneumoniae

Viral-bacterial coinfections, such as with influenza A virus and Streptococcus pneumoniae (S.p.), are known to cause severe pneumonia. It is well known that the host response has an important role in disease. Interleukin-1β (IL-1β) is an important immune signaling cytokine responsible for inflammati...

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Detalles Bibliográficos
Autores principales: Rodriguez, Angeline E., Bogart, Christopher, Gilbert, Christopher M., McCullers, Jonathan A., Smith, Amber M., Kanneganti, Thirumala-Devi, Lupfer, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386446/
https://www.ncbi.nlm.nih.gov/pubmed/30794604
http://dx.doi.org/10.1371/journal.pone.0212236

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