Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora

Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L(-1), 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway reveal...

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Detalles Bibliográficos
Autores principales: Subban, Kamalraj, Subramani, Ramesh, Srinivasan, Vishnu Priya Madambakkam, Johnpaul, Muthumary, Chelliah, Jayabaskaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386501/
https://www.ncbi.nlm.nih.gov/pubmed/30794656
http://dx.doi.org/10.1371/journal.pone.0212736
Descripción
Sumario:Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L(-1), 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora.

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