Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora

Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L(-1), 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway reveal...

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Autores principales: Subban, Kamalraj, Subramani, Ramesh, Srinivasan, Vishnu Priya Madambakkam, Johnpaul, Muthumary, Chelliah, Jayabaskaran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386501/
https://www.ncbi.nlm.nih.gov/pubmed/30794656
http://dx.doi.org/10.1371/journal.pone.0212736
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author Subban, Kamalraj
Subramani, Ramesh
Srinivasan, Vishnu Priya Madambakkam
Johnpaul, Muthumary
Chelliah, Jayabaskaran
author_facet Subban, Kamalraj
Subramani, Ramesh
Srinivasan, Vishnu Priya Madambakkam
Johnpaul, Muthumary
Chelliah, Jayabaskaran
author_sort Subban, Kamalraj
collection PubMed
description Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L(-1), 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora.
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spelling pubmed-63865012019-03-09 Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora Subban, Kamalraj Subramani, Ramesh Srinivasan, Vishnu Priya Madambakkam Johnpaul, Muthumary Chelliah, Jayabaskaran PLoS One Research Article Salicylic acid (SA) is an effective elicitor to increase taxol production in Pestalotiopsis microspora. Addition of SA at the concentration of 300 μM yielded taxol 625.47 μg L(-1), 45- fold higher than that of the control. Elicitation of the role of SA in the fungal taxol biosynthetic pathway revealed that SA enhanced reactive oxygen species and lipid peroxidation of unsaturated fatty acids of P. microspora mycelia. This oxidative process stimulates isoprene biosynthetic pathway by triggering expression of the geranylgeranyl pyrophosphate synthase gene leading to improved biosynthesis of taxol in P. microspora. Public Library of Science 2019-02-22 /pmc/articles/PMC6386501/ /pubmed/30794656 http://dx.doi.org/10.1371/journal.pone.0212736 Text en © 2019 Subban et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Subban, Kamalraj
Subramani, Ramesh
Srinivasan, Vishnu Priya Madambakkam
Johnpaul, Muthumary
Chelliah, Jayabaskaran
Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
title Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
title_full Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
title_fullStr Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
title_full_unstemmed Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
title_short Salicylic acid as an effective elicitor for improved taxol production in endophytic fungus Pestalotiopsis microspora
title_sort salicylic acid as an effective elicitor for improved taxol production in endophytic fungus pestalotiopsis microspora
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386501/
https://www.ncbi.nlm.nih.gov/pubmed/30794656
http://dx.doi.org/10.1371/journal.pone.0212736
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