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Nano-bio-computing lipid nanotablet
Using nanoparticles as substrates for computation enables algorithmic and autonomous controls of their unique and beneficial properties. However, scalable architecture for nanoparticle-based computing systems is lacking. Here, we report a platform for constructing nanoparticle logic gates and circui...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Association for the Advancement of Science
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386558/ https://www.ncbi.nlm.nih.gov/pubmed/30801008 http://dx.doi.org/10.1126/sciadv.aau2124 |
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author | Seo, Jinyoung Kim, Sungi Park, Ha H. Choi, Da Yeon Nam, Jwa-Min |
author_facet | Seo, Jinyoung Kim, Sungi Park, Ha H. Choi, Da Yeon Nam, Jwa-Min |
author_sort | Seo, Jinyoung |
collection | PubMed |
description | Using nanoparticles as substrates for computation enables algorithmic and autonomous controls of their unique and beneficial properties. However, scalable architecture for nanoparticle-based computing systems is lacking. Here, we report a platform for constructing nanoparticle logic gates and circuits at the single-particle level on a supported lipid bilayer. Our “lipid nanotablet” platform, inspired by cellular membranes that are exploited to compartmentalize and control signaling networks, uses a lipid bilayer as a chemical circuit board and nanoparticles as computational units. On a lipid nanotablet, a single-nanoparticle logic gate senses molecules in solution as inputs and triggers particle assembly or disassembly as an output. We demonstrate a set of Boolean logic operations, fan-in/fan-out of logic gates, and a combinational logic circuit such as a multiplexer. We envisage that our approach to modularly implement nanoparticle circuits on a lipid bilayer will create new paradigms and opportunities in molecular computing, nanoparticle circuits, and systems nanoscience. |
format | Online Article Text |
id | pubmed-6386558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | American Association for the Advancement of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-63865582019-02-23 Nano-bio-computing lipid nanotablet Seo, Jinyoung Kim, Sungi Park, Ha H. Choi, Da Yeon Nam, Jwa-Min Sci Adv Research Articles Using nanoparticles as substrates for computation enables algorithmic and autonomous controls of their unique and beneficial properties. However, scalable architecture for nanoparticle-based computing systems is lacking. Here, we report a platform for constructing nanoparticle logic gates and circuits at the single-particle level on a supported lipid bilayer. Our “lipid nanotablet” platform, inspired by cellular membranes that are exploited to compartmentalize and control signaling networks, uses a lipid bilayer as a chemical circuit board and nanoparticles as computational units. On a lipid nanotablet, a single-nanoparticle logic gate senses molecules in solution as inputs and triggers particle assembly or disassembly as an output. We demonstrate a set of Boolean logic operations, fan-in/fan-out of logic gates, and a combinational logic circuit such as a multiplexer. We envisage that our approach to modularly implement nanoparticle circuits on a lipid bilayer will create new paradigms and opportunities in molecular computing, nanoparticle circuits, and systems nanoscience. American Association for the Advancement of Science 2019-02-22 /pmc/articles/PMC6386558/ /pubmed/30801008 http://dx.doi.org/10.1126/sciadv.aau2124 Text en Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). http://creativecommons.org/licenses/by-nc/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (http://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited. |
spellingShingle | Research Articles Seo, Jinyoung Kim, Sungi Park, Ha H. Choi, Da Yeon Nam, Jwa-Min Nano-bio-computing lipid nanotablet |
title | Nano-bio-computing lipid nanotablet |
title_full | Nano-bio-computing lipid nanotablet |
title_fullStr | Nano-bio-computing lipid nanotablet |
title_full_unstemmed | Nano-bio-computing lipid nanotablet |
title_short | Nano-bio-computing lipid nanotablet |
title_sort | nano-bio-computing lipid nanotablet |
topic | Research Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386558/ https://www.ncbi.nlm.nih.gov/pubmed/30801008 http://dx.doi.org/10.1126/sciadv.aau2124 |
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