Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood. Here we show that growing budding yeast and primary mammalian cells beyond a...

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Detalles Bibliográficos
Autores principales: Neurohr, Gabriel E., Terry, Rachel L., Lengefeld, Jette, Bonney, Megan, Brittingham, Gregory P., Moretto, Fabien, Miettinen, Teemu P., Vaites, Laura Pontano, Soares, Luis M., Paulo, Joao A., Harper, J. Wade, Buratowski, Stephen, Manalis, Scott, van Werven, Folkert J., Holt, Liam J., Amon, Angelika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386581/
https://www.ncbi.nlm.nih.gov/pubmed/30739799
http://dx.doi.org/10.1016/j.cell.2019.01.018

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