CD4 receptor diversity in chimpanzees protects against SIV infection

Human and simian immunodeficiency viruses (HIV/SIVs) use CD4 as the primary receptor to enter target cells. Here, we show that the chimpanzee CD4 is highly polymorphic, with nine coding variants present in wild populations, and that this diversity interferes with SIV envelope (Env)–CD4 interactions....

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Detalles Bibliográficos
Autores principales: Bibollet-Ruche, Frederic, Russell, Ronnie M., Liu, Weimin, Stewart-Jones, Guillaume B. E., Sherrill-Mix, Scott, Li, Yingying, Learn, Gerald H., Smith, Andrew G., Gondim, Marcos V. P., Plenderleith, Lindsey J., Decker, Julie M., Easlick, Juliet L., Wetzel, Katherine S., Collman, Ronald G., Ding, Shilei, Finzi, Andrés, Ayouba, Ahidjo, Peeters, Martine, Leendertz, Fabian H., van Schijndel, Joost, Goedmakers, Annemarie, Ton, Els, Boesch, Christophe, Kuehl, Hjalmar, Arandjelovic, Mimi, Dieguez, Paula, Murai, Mizuki, Colin, Christelle, Koops, Kathelijne, Speede, Sheri, Gonder, Mary K., Muller, Martin N., Sanz, Crickette M., Morgan, David B., Atencia, Rebecca, Cox, Debby, Piel, Alex K., Stewart, Fiona A., Ndjango, Jean-Bosco N., Mjungu, Deus, Lonsdorf, Elizabeth V., Pusey, Anne E., Kwong, Peter D., Sharp, Paul M., Shaw, George M., Hahn, Beatrice H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386711/
https://www.ncbi.nlm.nih.gov/pubmed/30718403
http://dx.doi.org/10.1073/pnas.1821197116

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