Diverse GPCRs exhibit conserved water networks for stabilization and activation

G protein-coupled receptors (GPCRs) have evolved to recognize incredibly diverse extracellular ligands while sharing a common architecture and structurally conserved intracellular signaling partners. It remains unclear how binding of diverse ligands brings about GPCR activation, the common structura...

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Detalles Bibliográficos
Autores principales: Venkatakrishnan, A. J., Ma, Anthony K., Fonseca, Rasmus, Latorraca, Naomi R., Kelly, Brendan, Betz, Robin M., Asawa, Chaitanya, Kobilka, Brian K., Dror, Ron O.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386714/
https://www.ncbi.nlm.nih.gov/pubmed/30728297
http://dx.doi.org/10.1073/pnas.1809251116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386714/
https://www.ncbi.nlm.nih.gov/pubmed/30728297
http://dx.doi.org/10.1073/pnas.1809251116

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