Humanized UGT2 and CYP3A transchromosomic rats for improved prediction of human drug metabolism

Although “genomically” humanized animals are invaluable tools for generating human disease models as well as for biomedical research, their development has been mainly restricted to mice via established transgenic-based and embryonic stem cell-based technologies. Since rats are widely used for study...

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Detalles Bibliográficos
Autores principales: Kazuki, Yasuhiro, Kobayashi, Kaoru, Hirabayashi, Masumi, Abe, Satoshi, Kajitani, Naoyo, Kazuki, Kanako, Takehara, Shoko, Takiguchi, Masato, Satoh, Daisuke, Kuze, Jiro, Sakuma, Tetsushi, Kaneko, Takehito, Mashimo, Tomoji, Osamura, Minori, Hashimoto, Mari, Wakatsuki, Riko, Hirashima, Rika, Fujiwara, Ryoichi, Deguchi, Tsuneo, Kurihara, Atsushi, Tsukazaki, Yasuko, Senda, Naoto, Yamamoto, Takashi, Scheer, Nico, Oshimura, Mitsuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2019
Materias:
PNAS Plus
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386724/
https://www.ncbi.nlm.nih.gov/pubmed/30718425
http://dx.doi.org/10.1073/pnas.1808255116

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