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Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know

Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be sus...

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Autores principales: Alessandrino, Francesco, DiPiro, Pamela J., Jagannathan, Jyothi P., Babina, Gosangi, Krajewski, Katherine M., Ramaiya, Nikhil H., Giardino, Angela A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386758/
https://www.ncbi.nlm.nih.gov/pubmed/30796644
http://dx.doi.org/10.1186/s13244-019-0705-y
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author Alessandrino, Francesco
DiPiro, Pamela J.
Jagannathan, Jyothi P.
Babina, Gosangi
Krajewski, Katherine M.
Ramaiya, Nikhil H.
Giardino, Angela A.
author_facet Alessandrino, Francesco
DiPiro, Pamela J.
Jagannathan, Jyothi P.
Babina, Gosangi
Krajewski, Katherine M.
Ramaiya, Nikhil H.
Giardino, Angela A.
author_sort Alessandrino, Francesco
collection PubMed
description Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be suspected on cross-sectional imaging when disproportionate lymph node enlargement or new focal lesions in extranodal organs are seen. On PET/CT, transformed indolent lymphoma may show new or increased nodal FDG avidity or new FDG-avid lesions in different organs. In this article, we will (1) review the imaging features of different subtypes of indolent B cell lymphomas, (2) discuss the imaging features of histologic transformation, and (3) propose a diagnostic algorithm for transformed indolent lymphoma. The purpose of this review is to familiarize radiologists with the spectrum of clinical and imaging features of indolent B cell lymphomas and to define the role of imaging in raising concern for transformation and in guiding biopsy for confirmation.
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spelling pubmed-63867582019-03-12 Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know Alessandrino, Francesco DiPiro, Pamela J. Jagannathan, Jyothi P. Babina, Gosangi Krajewski, Katherine M. Ramaiya, Nikhil H. Giardino, Angela A. Insights Imaging Pictorial Review Indolent B cell lymphomas are a group of lymphoid malignancies characterized by their potential to undergo histologic transformation to aggressive lymphomas. While different subtypes of indolent B cell lymphomas demonstrate specific clinical and imaging features, histologic transformation can be suspected on cross-sectional imaging when disproportionate lymph node enlargement or new focal lesions in extranodal organs are seen. On PET/CT, transformed indolent lymphoma may show new or increased nodal FDG avidity or new FDG-avid lesions in different organs. In this article, we will (1) review the imaging features of different subtypes of indolent B cell lymphomas, (2) discuss the imaging features of histologic transformation, and (3) propose a diagnostic algorithm for transformed indolent lymphoma. The purpose of this review is to familiarize radiologists with the spectrum of clinical and imaging features of indolent B cell lymphomas and to define the role of imaging in raising concern for transformation and in guiding biopsy for confirmation. Springer Berlin Heidelberg 2019-02-22 /pmc/articles/PMC6386758/ /pubmed/30796644 http://dx.doi.org/10.1186/s13244-019-0705-y Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Pictorial Review
Alessandrino, Francesco
DiPiro, Pamela J.
Jagannathan, Jyothi P.
Babina, Gosangi
Krajewski, Katherine M.
Ramaiya, Nikhil H.
Giardino, Angela A.
Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
title Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
title_full Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
title_fullStr Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
title_full_unstemmed Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
title_short Multimodality imaging of indolent B cell lymphoma from diagnosis to transformation: what every radiologist should know
title_sort multimodality imaging of indolent b cell lymphoma from diagnosis to transformation: what every radiologist should know
topic Pictorial Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386758/
https://www.ncbi.nlm.nih.gov/pubmed/30796644
http://dx.doi.org/10.1186/s13244-019-0705-y
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