Cargando…

Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia

The programmed cell death protein 1 (PD-1) receptor has been reported to downregulate T cell activation effectively via binding to its ligands PD-L1 or PD-L2 in a negative co-stimulatory manner. Little is known about the involvement of PD-1 mediated immunoregulation in pregnancy and in pregnancy-rel...

Descripción completa

Detalles Bibliográficos
Autores principales: Meggyes, Matyas, Miko, Eva, Lajko, Adrienn, Csiszar, Beata, Sandor, Barbara, Matrai, Peter, Tamas, Peter, Szereday, Laszlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386834/
https://www.ncbi.nlm.nih.gov/pubmed/30700015
http://dx.doi.org/10.3390/ijms20030583
_version_ 1783397432893112320
author Meggyes, Matyas
Miko, Eva
Lajko, Adrienn
Csiszar, Beata
Sandor, Barbara
Matrai, Peter
Tamas, Peter
Szereday, Laszlo
author_facet Meggyes, Matyas
Miko, Eva
Lajko, Adrienn
Csiszar, Beata
Sandor, Barbara
Matrai, Peter
Tamas, Peter
Szereday, Laszlo
author_sort Meggyes, Matyas
collection PubMed
description The programmed cell death protein 1 (PD-1) receptor has been reported to downregulate T cell activation effectively via binding to its ligands PD-L1 or PD-L2 in a negative co-stimulatory manner. Little is known about the involvement of PD-1 mediated immunoregulation in pregnancy and in pregnancy-related disorders. In this work, we investigated the possible role of the PD-1 co-stimulatory pathway in the pathogenesis of the clinical phase of early-onset preeclampsia characterized by a systemic maternal inflammatory response. We performed a cross-sectional study for comparative analysis of phenotypic and functional characteristics of peripheral blood mononuclear cells in women with early-onset preeclampsia and third-trimester healthy pregnant controls. According to our findings, enhanced expression of either PD-1 or its ligand PD-L1, or both, on the cell surface of effector cells (T cells, natural killer (NK) cells, natural killer T (NKT)-like cells) and Tregs could be observed, but PD-1 expression did not correlate with effector cells exhaustion. These results suggest the failure of the axis to downregulate Th1 responses, contributing thereby to the exaggerated immunoactivation observed in early-onset preeclampsia.
format Online
Article
Text
id pubmed-6386834
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-63868342019-02-27 Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia Meggyes, Matyas Miko, Eva Lajko, Adrienn Csiszar, Beata Sandor, Barbara Matrai, Peter Tamas, Peter Szereday, Laszlo Int J Mol Sci Article The programmed cell death protein 1 (PD-1) receptor has been reported to downregulate T cell activation effectively via binding to its ligands PD-L1 or PD-L2 in a negative co-stimulatory manner. Little is known about the involvement of PD-1 mediated immunoregulation in pregnancy and in pregnancy-related disorders. In this work, we investigated the possible role of the PD-1 co-stimulatory pathway in the pathogenesis of the clinical phase of early-onset preeclampsia characterized by a systemic maternal inflammatory response. We performed a cross-sectional study for comparative analysis of phenotypic and functional characteristics of peripheral blood mononuclear cells in women with early-onset preeclampsia and third-trimester healthy pregnant controls. According to our findings, enhanced expression of either PD-1 or its ligand PD-L1, or both, on the cell surface of effector cells (T cells, natural killer (NK) cells, natural killer T (NKT)-like cells) and Tregs could be observed, but PD-1 expression did not correlate with effector cells exhaustion. These results suggest the failure of the axis to downregulate Th1 responses, contributing thereby to the exaggerated immunoactivation observed in early-onset preeclampsia. MDPI 2019-01-29 /pmc/articles/PMC6386834/ /pubmed/30700015 http://dx.doi.org/10.3390/ijms20030583 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Meggyes, Matyas
Miko, Eva
Lajko, Adrienn
Csiszar, Beata
Sandor, Barbara
Matrai, Peter
Tamas, Peter
Szereday, Laszlo
Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia
title Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia
title_full Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia
title_fullStr Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia
title_full_unstemmed Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia
title_short Involvement of the PD-1/PD-L1 Co-Inhibitory Pathway in the Pathogenesis of the Inflammatory Stage of Early-Onset Preeclampsia
title_sort involvement of the pd-1/pd-l1 co-inhibitory pathway in the pathogenesis of the inflammatory stage of early-onset preeclampsia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386834/
https://www.ncbi.nlm.nih.gov/pubmed/30700015
http://dx.doi.org/10.3390/ijms20030583
work_keys_str_mv AT meggyesmatyas involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT mikoeva involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT lajkoadrienn involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT csiszarbeata involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT sandorbarbara involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT matraipeter involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT tamaspeter involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia
AT szeredaylaszlo involvementofthepd1pdl1coinhibitorypathwayinthepathogenesisoftheinflammatorystageofearlyonsetpreeclampsia