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Podoplanin in Inflammation and Cancer
Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system. Emerging evidence indicates that it is also involved in the control of mammary stem-cell activity and biogenesis of platelets in the bone marr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386838/ https://www.ncbi.nlm.nih.gov/pubmed/30736372 http://dx.doi.org/10.3390/ijms20030707 |
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author | Quintanilla, Miguel Montero-Montero, Lucía Renart, Jaime Martín-Villar, Ester |
author_facet | Quintanilla, Miguel Montero-Montero, Lucía Renart, Jaime Martín-Villar, Ester |
author_sort | Quintanilla, Miguel |
collection | PubMed |
description | Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system. Emerging evidence indicates that it is also involved in the control of mammary stem-cell activity and biogenesis of platelets in the bone marrow, and exerts an important function in the immune response. Podoplanin expression is upregulated in different cell types, including fibroblasts, macrophages, T helper cells, and epithelial cells, during inflammation and cancer, where it plays important roles. Podoplanin is implicated in chronic inflammatory diseases, such as psoriasis, multiple sclerosis, and rheumatoid arthritis, promotes inflammation-driven and cancer-associated thrombosis, and stimulates cancer cell invasion and metastasis through a variety of strategies. To accomplish its biological functions, podoplanin must interact with other proteins located in the same cell or in neighbor cells. The binding of podoplanin to its ligands leads to modulation of signaling pathways that regulate proliferation, contractility, migration, epithelial–mesenchymal transition, and remodeling of the extracellular matrix. In this review, we describe the diverse roles of podoplanin in inflammation and cancer, depict the protein ligands of podoplanin identified so far, and discuss the mechanistic basis for the involvement of podoplanin in all these processes. |
format | Online Article Text |
id | pubmed-6386838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63868382019-02-27 Podoplanin in Inflammation and Cancer Quintanilla, Miguel Montero-Montero, Lucía Renart, Jaime Martín-Villar, Ester Int J Mol Sci Review Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the development of the alveoli, heart, and lymphatic vascular system. Emerging evidence indicates that it is also involved in the control of mammary stem-cell activity and biogenesis of platelets in the bone marrow, and exerts an important function in the immune response. Podoplanin expression is upregulated in different cell types, including fibroblasts, macrophages, T helper cells, and epithelial cells, during inflammation and cancer, where it plays important roles. Podoplanin is implicated in chronic inflammatory diseases, such as psoriasis, multiple sclerosis, and rheumatoid arthritis, promotes inflammation-driven and cancer-associated thrombosis, and stimulates cancer cell invasion and metastasis through a variety of strategies. To accomplish its biological functions, podoplanin must interact with other proteins located in the same cell or in neighbor cells. The binding of podoplanin to its ligands leads to modulation of signaling pathways that regulate proliferation, contractility, migration, epithelial–mesenchymal transition, and remodeling of the extracellular matrix. In this review, we describe the diverse roles of podoplanin in inflammation and cancer, depict the protein ligands of podoplanin identified so far, and discuss the mechanistic basis for the involvement of podoplanin in all these processes. MDPI 2019-02-06 /pmc/articles/PMC6386838/ /pubmed/30736372 http://dx.doi.org/10.3390/ijms20030707 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Quintanilla, Miguel Montero-Montero, Lucía Renart, Jaime Martín-Villar, Ester Podoplanin in Inflammation and Cancer |
title | Podoplanin in Inflammation and Cancer |
title_full | Podoplanin in Inflammation and Cancer |
title_fullStr | Podoplanin in Inflammation and Cancer |
title_full_unstemmed | Podoplanin in Inflammation and Cancer |
title_short | Podoplanin in Inflammation and Cancer |
title_sort | podoplanin in inflammation and cancer |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386838/ https://www.ncbi.nlm.nih.gov/pubmed/30736372 http://dx.doi.org/10.3390/ijms20030707 |
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