Parkin Interacts with Apoptosis-Inducing Factor and Interferes with Its Translocation to the Nucleus in Neuronal Cells

Mutations in the PRKN gene (encoding parkin) have been linked to the most frequent known cause of recessive Parkinson’s disease (PD), and parkin dysfunction represents a risk factor for sporadic PD. Parkin is widely neuroprotective through different cellular pathways, as it protects dopaminergic neu...

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Detalles Bibliográficos
Autores principales: Guida, Marianna, Zanon, Alessandra, Montibeller, Luigi, Lavdas, Alexandros A., Ladurner, Judith, Pischedda, Francesca, Rakovic, Aleksandar, Domingues, Francisco S., Piccoli, Giovanni, Klein, Christine, Pramstaller, Peter P., Hicks, Andrew A., Pichler, Irene
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386878/
https://www.ncbi.nlm.nih.gov/pubmed/30754623
http://dx.doi.org/10.3390/ijms20030748

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