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Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link

Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which ex...

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Autores principales: Bok, Eugene, Jo, Myungjin, Lee, Shinrye, Lee, Bo-Ram, Kim, Jaekwang, Kim, Hyung-Jun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386998/
https://www.ncbi.nlm.nih.gov/pubmed/30678217
http://dx.doi.org/10.3390/ijms20030464
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author Bok, Eugene
Jo, Myungjin
Lee, Shinrye
Lee, Bo-Ram
Kim, Jaekwang
Kim, Hyung-Jun
author_facet Bok, Eugene
Jo, Myungjin
Lee, Shinrye
Lee, Bo-Ram
Kim, Jaekwang
Kim, Hyung-Jun
author_sort Bok, Eugene
collection PubMed
description Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-related proinflammatory activation of astrocytes and microglia is attenuated under DR. However, the molecular mechanisms underlying DR-mediated regulation of neuroinflammation are not well understood. Here, we review the current understanding of the effects of DR on neuroinflammation and suggest an underlying mechanistic link between DR and neuroinflammation that may provide novel insights into the role of DR in aging and age-associated brain disorders.
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spelling pubmed-63869982019-02-27 Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link Bok, Eugene Jo, Myungjin Lee, Shinrye Lee, Bo-Ram Kim, Jaekwang Kim, Hyung-Jun Int J Mol Sci Review Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-related proinflammatory activation of astrocytes and microglia is attenuated under DR. However, the molecular mechanisms underlying DR-mediated regulation of neuroinflammation are not well understood. Here, we review the current understanding of the effects of DR on neuroinflammation and suggest an underlying mechanistic link between DR and neuroinflammation that may provide novel insights into the role of DR in aging and age-associated brain disorders. MDPI 2019-01-22 /pmc/articles/PMC6386998/ /pubmed/30678217 http://dx.doi.org/10.3390/ijms20030464 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Bok, Eugene
Jo, Myungjin
Lee, Shinrye
Lee, Bo-Ram
Kim, Jaekwang
Kim, Hyung-Jun
Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
title Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
title_full Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
title_fullStr Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
title_full_unstemmed Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
title_short Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
title_sort dietary restriction and neuroinflammation: a potential mechanistic link
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386998/
https://www.ncbi.nlm.nih.gov/pubmed/30678217
http://dx.doi.org/10.3390/ijms20030464
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