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Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link
Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which ex...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386998/ https://www.ncbi.nlm.nih.gov/pubmed/30678217 http://dx.doi.org/10.3390/ijms20030464 |
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author | Bok, Eugene Jo, Myungjin Lee, Shinrye Lee, Bo-Ram Kim, Jaekwang Kim, Hyung-Jun |
author_facet | Bok, Eugene Jo, Myungjin Lee, Shinrye Lee, Bo-Ram Kim, Jaekwang Kim, Hyung-Jun |
author_sort | Bok, Eugene |
collection | PubMed |
description | Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-related proinflammatory activation of astrocytes and microglia is attenuated under DR. However, the molecular mechanisms underlying DR-mediated regulation of neuroinflammation are not well understood. Here, we review the current understanding of the effects of DR on neuroinflammation and suggest an underlying mechanistic link between DR and neuroinflammation that may provide novel insights into the role of DR in aging and age-associated brain disorders. |
format | Online Article Text |
id | pubmed-6386998 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63869982019-02-27 Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link Bok, Eugene Jo, Myungjin Lee, Shinrye Lee, Bo-Ram Kim, Jaekwang Kim, Hyung-Jun Int J Mol Sci Review Chronic neuroinflammation is a common feature of the aged brain, and its association with the major neurodegenerative changes involved in cognitive impairment and motor dysfunction is well established. One of the most potent antiaging interventions tested so far is dietary restriction (DR), which extends the lifespan in various organisms. Microglia and astrocytes are two major types of glial cells involved in the regulation of neuroinflammation. Accumulating evidence suggests that the age-related proinflammatory activation of astrocytes and microglia is attenuated under DR. However, the molecular mechanisms underlying DR-mediated regulation of neuroinflammation are not well understood. Here, we review the current understanding of the effects of DR on neuroinflammation and suggest an underlying mechanistic link between DR and neuroinflammation that may provide novel insights into the role of DR in aging and age-associated brain disorders. MDPI 2019-01-22 /pmc/articles/PMC6386998/ /pubmed/30678217 http://dx.doi.org/10.3390/ijms20030464 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Bok, Eugene Jo, Myungjin Lee, Shinrye Lee, Bo-Ram Kim, Jaekwang Kim, Hyung-Jun Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link |
title | Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link |
title_full | Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link |
title_fullStr | Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link |
title_full_unstemmed | Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link |
title_short | Dietary Restriction and Neuroinflammation: A Potential Mechanistic Link |
title_sort | dietary restriction and neuroinflammation: a potential mechanistic link |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6386998/ https://www.ncbi.nlm.nih.gov/pubmed/30678217 http://dx.doi.org/10.3390/ijms20030464 |
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