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Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387250/ https://www.ncbi.nlm.nih.gov/pubmed/30744200 http://dx.doi.org/10.3390/ijms20030745 |
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author | Shishkin, Sergey S. Kovalev, Leonid I. Pashintseva, Natalya V. Kovaleva, Marina A. Lisitskaya, Ksenia |
author_facet | Shishkin, Sergey S. Kovalev, Leonid I. Pashintseva, Natalya V. Kovaleva, Marina A. Lisitskaya, Ksenia |
author_sort | Shishkin, Sergey S. |
collection | PubMed |
description | Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs. |
format | Online Article Text |
id | pubmed-6387250 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63872502019-02-27 Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells Shishkin, Sergey S. Kovalev, Leonid I. Pashintseva, Natalya V. Kovaleva, Marina A. Lisitskaya, Ksenia Int J Mol Sci Review Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs. MDPI 2019-02-10 /pmc/articles/PMC6387250/ /pubmed/30744200 http://dx.doi.org/10.3390/ijms20030745 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Shishkin, Sergey S. Kovalev, Leonid I. Pashintseva, Natalya V. Kovaleva, Marina A. Lisitskaya, Ksenia Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells |
title | Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells |
title_full | Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells |
title_fullStr | Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells |
title_full_unstemmed | Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells |
title_short | Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells |
title_sort | heterogeneous nuclear ribonucleoproteins involved in the functioning of telomeres in malignant cells |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387250/ https://www.ncbi.nlm.nih.gov/pubmed/30744200 http://dx.doi.org/10.3390/ijms20030745 |
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