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Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells

Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most...

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Autores principales: Shishkin, Sergey S., Kovalev, Leonid I., Pashintseva, Natalya V., Kovaleva, Marina A., Lisitskaya, Ksenia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387250/
https://www.ncbi.nlm.nih.gov/pubmed/30744200
http://dx.doi.org/10.3390/ijms20030745
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author Shishkin, Sergey S.
Kovalev, Leonid I.
Pashintseva, Natalya V.
Kovaleva, Marina A.
Lisitskaya, Ksenia
author_facet Shishkin, Sergey S.
Kovalev, Leonid I.
Pashintseva, Natalya V.
Kovaleva, Marina A.
Lisitskaya, Ksenia
author_sort Shishkin, Sergey S.
collection PubMed
description Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs.
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spelling pubmed-63872502019-02-27 Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells Shishkin, Sergey S. Kovalev, Leonid I. Pashintseva, Natalya V. Kovaleva, Marina A. Lisitskaya, Ksenia Int J Mol Sci Review Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1—the most studied hnRNP—is an abundant multifunctional protein that interacts with telomeric DNA and affects telomerase function. In addition, it is believed that other hnRNPs in HMCs may also be involved in the maintenance of telomere length. Accordingly, these proteins are considered possible participants in the processes associated with HMC immortalization. In our review, we discuss the results of studies on different hnRNPs that may be crucial to solving molecular oncological problems and relevant to further investigations of these proteins in HMCs. MDPI 2019-02-10 /pmc/articles/PMC6387250/ /pubmed/30744200 http://dx.doi.org/10.3390/ijms20030745 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Shishkin, Sergey S.
Kovalev, Leonid I.
Pashintseva, Natalya V.
Kovaleva, Marina A.
Lisitskaya, Ksenia
Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_full Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_fullStr Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_full_unstemmed Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_short Heterogeneous Nuclear Ribonucleoproteins Involved in the Functioning of Telomeres in Malignant Cells
title_sort heterogeneous nuclear ribonucleoproteins involved in the functioning of telomeres in malignant cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387250/
https://www.ncbi.nlm.nih.gov/pubmed/30744200
http://dx.doi.org/10.3390/ijms20030745
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