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Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer

Natural killer (NK) cells have received a lot of attention in recent years for the roles they play in immunity and particularly in antitumor immune responses. Although defects in NK cell functions are recognized as important mechanisms for immune evasion of malignant cells, molecular pathways regula...

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Autores principales: Zakiryanova, Gulnur K., Kustova, Elena, Urazalieva, Nataliya T., Baimuchametov, Emile T., Nakisbekov, Narymzhan N., Shurin, Michael R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387292/
https://www.ncbi.nlm.nih.gov/pubmed/30754645
http://dx.doi.org/10.3390/ijms20030756
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author Zakiryanova, Gulnur K.
Kustova, Elena
Urazalieva, Nataliya T.
Baimuchametov, Emile T.
Nakisbekov, Narymzhan N.
Shurin, Michael R.
author_facet Zakiryanova, Gulnur K.
Kustova, Elena
Urazalieva, Nataliya T.
Baimuchametov, Emile T.
Nakisbekov, Narymzhan N.
Shurin, Michael R.
author_sort Zakiryanova, Gulnur K.
collection PubMed
description Natural killer (NK) cells have received a lot of attention in recent years for the roles they play in immunity and particularly in antitumor immune responses. Although defects in NK cell functions are recognized as important mechanisms for immune evasion of malignant cells, molecular pathways regulating NK cell dysfunction and exhaustion in cancer are largely unknown. Here we tested whether the c-myc proto-oncogene, known to promote cell proliferation, growth, differentiation, and apoptosis by regulating the expression of numerous target genes, may be involved in the mechanism of NK cell abnormalities in patients with lung and gastric cancer. Analysis of c-myc mRNA and protein expression in peripheral blood NK cells, mitogen-activated protein kinase (MAPK) activity, cell cycle, and cell longevity revealed a significantly decreased expression of c-myc mRNA and protein and mitotic arrest of NK cells in different phases of cell cycle. In addition, a significant decrease of NK cell death was also detected. These data allow the suggestion that defects of NK cell-mediated tumor surveillance may be associated with disturbed c-myc expression in NK cells in cancer patients. A better understanding of the mechanisms of NK cell dysfunction in cancer will help in the NK cell-mediated therapeutic eradication of primary and metastatic cancer cells and prolong patient survival.
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spelling pubmed-63872922019-02-27 Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer Zakiryanova, Gulnur K. Kustova, Elena Urazalieva, Nataliya T. Baimuchametov, Emile T. Nakisbekov, Narymzhan N. Shurin, Michael R. Int J Mol Sci Article Natural killer (NK) cells have received a lot of attention in recent years for the roles they play in immunity and particularly in antitumor immune responses. Although defects in NK cell functions are recognized as important mechanisms for immune evasion of malignant cells, molecular pathways regulating NK cell dysfunction and exhaustion in cancer are largely unknown. Here we tested whether the c-myc proto-oncogene, known to promote cell proliferation, growth, differentiation, and apoptosis by regulating the expression of numerous target genes, may be involved in the mechanism of NK cell abnormalities in patients with lung and gastric cancer. Analysis of c-myc mRNA and protein expression in peripheral blood NK cells, mitogen-activated protein kinase (MAPK) activity, cell cycle, and cell longevity revealed a significantly decreased expression of c-myc mRNA and protein and mitotic arrest of NK cells in different phases of cell cycle. In addition, a significant decrease of NK cell death was also detected. These data allow the suggestion that defects of NK cell-mediated tumor surveillance may be associated with disturbed c-myc expression in NK cells in cancer patients. A better understanding of the mechanisms of NK cell dysfunction in cancer will help in the NK cell-mediated therapeutic eradication of primary and metastatic cancer cells and prolong patient survival. MDPI 2019-02-11 /pmc/articles/PMC6387292/ /pubmed/30754645 http://dx.doi.org/10.3390/ijms20030756 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zakiryanova, Gulnur K.
Kustova, Elena
Urazalieva, Nataliya T.
Baimuchametov, Emile T.
Nakisbekov, Narymzhan N.
Shurin, Michael R.
Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer
title Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer
title_full Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer
title_fullStr Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer
title_full_unstemmed Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer
title_short Abnormal Expression of c-Myc Oncogene in NK Cells in Patients with Cancer
title_sort abnormal expression of c-myc oncogene in nk cells in patients with cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387292/
https://www.ncbi.nlm.nih.gov/pubmed/30754645
http://dx.doi.org/10.3390/ijms20030756
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