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Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes
In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both growth hormone deficiency (GHD) and GH excess have significan...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387392/ https://www.ncbi.nlm.nih.gov/pubmed/30759741 http://dx.doi.org/10.3390/ijms20030772 |
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author | Bonfig, Walter Holl, Reinhard W. |
author_facet | Bonfig, Walter Holl, Reinhard W. |
author_sort | Bonfig, Walter |
collection | PubMed |
description | In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both growth hormone deficiency (GHD) and GH excess have significant influence on carbohydrate metabolism. These complex interactions are challenging in diagnosing GHD in subjects with type 1 diabetes mellitus (T1DM) and in treating subjects with T1DM with GH. So far, there is only limited clinical experience in GH treatment in patients with T1DM, but recently first reports on metabolic safety and efficacy of GH treatment in subjects with T1DM have been published. |
format | Online Article Text |
id | pubmed-6387392 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-63873922019-02-27 Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes Bonfig, Walter Holl, Reinhard W. Int J Mol Sci Commentary In the state of insulin deficiency, the growth hormone—insulin-like growth factor-I (GH–IGF-I) axis is altered due to hepatic GH resistance, which leads to GH hypersecretion and low circulating IGF-I concentration. On the other hand, both growth hormone deficiency (GHD) and GH excess have significant influence on carbohydrate metabolism. These complex interactions are challenging in diagnosing GHD in subjects with type 1 diabetes mellitus (T1DM) and in treating subjects with T1DM with GH. So far, there is only limited clinical experience in GH treatment in patients with T1DM, but recently first reports on metabolic safety and efficacy of GH treatment in subjects with T1DM have been published. MDPI 2019-02-12 /pmc/articles/PMC6387392/ /pubmed/30759741 http://dx.doi.org/10.3390/ijms20030772 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Commentary Bonfig, Walter Holl, Reinhard W. Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes |
title | Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes |
title_full | Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes |
title_fullStr | Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes |
title_full_unstemmed | Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes |
title_short | Mini Review/Commentary: Growth Hormone Treatment in Children with Type 1 Diabetes |
title_sort | mini review/commentary: growth hormone treatment in children with type 1 diabetes |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387392/ https://www.ncbi.nlm.nih.gov/pubmed/30759741 http://dx.doi.org/10.3390/ijms20030772 |
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