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Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients

Infection with cytomegalovirus (CMV) remains a major problem in kidney transplant recipients, resulting in serious infectious complications and occasionally mortality. Accumulating evidence indicates that natural killer cell immunoglobulin-like receptors (KIRs) and their ligands affect the susceptib...

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Autores principales: Deborska-Materkowska, Dominika, Perkowska-Ptasinska, Agnieszka, Sadowska-Jakubowicz, Anna, Gozdowska, Jolanta, Ciszek, Michał, Pazik, Joanna, Ostaszewska, Agata, Kosieradzki, Maciej, Nowak, Jacek, Durlik, Magdalena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387393/
https://www.ncbi.nlm.nih.gov/pubmed/30696053
http://dx.doi.org/10.3390/ijms20030546
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author Deborska-Materkowska, Dominika
Perkowska-Ptasinska, Agnieszka
Sadowska-Jakubowicz, Anna
Gozdowska, Jolanta
Ciszek, Michał
Pazik, Joanna
Ostaszewska, Agata
Kosieradzki, Maciej
Nowak, Jacek
Durlik, Magdalena
author_facet Deborska-Materkowska, Dominika
Perkowska-Ptasinska, Agnieszka
Sadowska-Jakubowicz, Anna
Gozdowska, Jolanta
Ciszek, Michał
Pazik, Joanna
Ostaszewska, Agata
Kosieradzki, Maciej
Nowak, Jacek
Durlik, Magdalena
author_sort Deborska-Materkowska, Dominika
collection PubMed
description Infection with cytomegalovirus (CMV) remains a major problem in kidney transplant recipients, resulting in serious infectious complications and occasionally mortality. Accumulating evidence indicates that natural killer cell immunoglobulin-like receptors (KIRs) and their ligands affect the susceptibility to various diseases, including viral infections (e.g., CMV infection). We investigated whether KIR genes and their ligands affect the occurrence of CMV infection in a group of 138 kidney transplant recipients who were observed for 720 days posttransplantation. We typed the recipients for the presence of KIR genes (human leukocyte antigen C1 [HLA-C1], HLA-C2, HLA-A, HLA-B, and HLA-DR1) by polymerase chain reaction with sequence-specific primers. The multivariate analysis revealed that the lack of KIR2DS2 (p = 0.035), the presence of KIR2DL3 (p = 0.075), and the presence of KIR2DL2–HLA-C1 (p = 0.044) were risk factors for posttransplant CMV infection. We also found that a lower estimated glomerular filtration rate (p = 0.036), an earlier time of antiviral prophylaxis initiation (p = 0.025), lymphocytopenia (p = 0.012), and pretransplant serostatus (donor-positive/recipient-negative; p = 0.042) were independent risk factors for posttransplant CMV infection. In conclusion, our findings confirm that the KIR/HLA genotype plays a significant role in anti-CMV immunity and suggest the contribution of both environmental and genetic factors to the incidence of CMV infection after kidney transplantation.
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spelling pubmed-63873932019-02-27 Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients Deborska-Materkowska, Dominika Perkowska-Ptasinska, Agnieszka Sadowska-Jakubowicz, Anna Gozdowska, Jolanta Ciszek, Michał Pazik, Joanna Ostaszewska, Agata Kosieradzki, Maciej Nowak, Jacek Durlik, Magdalena Int J Mol Sci Article Infection with cytomegalovirus (CMV) remains a major problem in kidney transplant recipients, resulting in serious infectious complications and occasionally mortality. Accumulating evidence indicates that natural killer cell immunoglobulin-like receptors (KIRs) and their ligands affect the susceptibility to various diseases, including viral infections (e.g., CMV infection). We investigated whether KIR genes and their ligands affect the occurrence of CMV infection in a group of 138 kidney transplant recipients who were observed for 720 days posttransplantation. We typed the recipients for the presence of KIR genes (human leukocyte antigen C1 [HLA-C1], HLA-C2, HLA-A, HLA-B, and HLA-DR1) by polymerase chain reaction with sequence-specific primers. The multivariate analysis revealed that the lack of KIR2DS2 (p = 0.035), the presence of KIR2DL3 (p = 0.075), and the presence of KIR2DL2–HLA-C1 (p = 0.044) were risk factors for posttransplant CMV infection. We also found that a lower estimated glomerular filtration rate (p = 0.036), an earlier time of antiviral prophylaxis initiation (p = 0.025), lymphocytopenia (p = 0.012), and pretransplant serostatus (donor-positive/recipient-negative; p = 0.042) were independent risk factors for posttransplant CMV infection. In conclusion, our findings confirm that the KIR/HLA genotype plays a significant role in anti-CMV immunity and suggest the contribution of both environmental and genetic factors to the incidence of CMV infection after kidney transplantation. MDPI 2019-01-28 /pmc/articles/PMC6387393/ /pubmed/30696053 http://dx.doi.org/10.3390/ijms20030546 Text en © 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Deborska-Materkowska, Dominika
Perkowska-Ptasinska, Agnieszka
Sadowska-Jakubowicz, Anna
Gozdowska, Jolanta
Ciszek, Michał
Pazik, Joanna
Ostaszewska, Agata
Kosieradzki, Maciej
Nowak, Jacek
Durlik, Magdalena
Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
title Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
title_full Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
title_fullStr Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
title_full_unstemmed Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
title_short Killer Immunoglobulin-Like Receptor 2DS2 (KIR2DS2), KIR2DL2-HLA-C1, and KIR2DL3 as Genetic Markers for Stratifying the Risk of Cytomegalovirus Infection in Kidney Transplant Recipients
title_sort killer immunoglobulin-like receptor 2ds2 (kir2ds2), kir2dl2-hla-c1, and kir2dl3 as genetic markers for stratifying the risk of cytomegalovirus infection in kidney transplant recipients
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387393/
https://www.ncbi.nlm.nih.gov/pubmed/30696053
http://dx.doi.org/10.3390/ijms20030546
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