Open questions: how to get developmental biology into shape?

Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenes...

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Detalles Bibliográficos
Autores principales: Saunders, Timothy E., Ingham, Philip W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Comment
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387480/
https://www.ncbi.nlm.nih.gov/pubmed/30795745
http://dx.doi.org/10.1186/s12915-019-0636-6
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author Saunders, Timothy E.
Ingham, Philip W.
author_facet Saunders, Timothy E.
Ingham, Philip W.
author_sort Saunders, Timothy E.
collection PubMed
description Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenesis and suggest how a synthesis between developmental biology and physics can help to address them.
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spelling pubmed-63874802019-03-04 Open questions: how to get developmental biology into shape? Saunders, Timothy E. Ingham, Philip W. BMC Biol Comment Recent technical advances have provided unprecedented insights into the selective deployment of the genome in developing organisms, but how such differential gene expression is used to sculpt the complex shapes and sizes of organs remains unclear. Here, we outline major open questions in organogenesis and suggest how a synthesis between developmental biology and physics can help to address them. BioMed Central 2019-02-22 /pmc/articles/PMC6387480/ /pubmed/30795745 http://dx.doi.org/10.1186/s12915-019-0636-6 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Comment
Saunders, Timothy E.
Ingham, Philip W.
Open questions: how to get developmental biology into shape?
title Open questions: how to get developmental biology into shape?
title_full Open questions: how to get developmental biology into shape?
title_fullStr Open questions: how to get developmental biology into shape?
title_full_unstemmed Open questions: how to get developmental biology into shape?
title_short Open questions: how to get developmental biology into shape?
title_sort open questions: how to get developmental biology into shape?
topic Comment
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387480/
https://www.ncbi.nlm.nih.gov/pubmed/30795745
http://dx.doi.org/10.1186/s12915-019-0636-6
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