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The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study

BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the assoc...

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Autores principales: Hattori, Hiromitsu, Kitamura, Akane, Takahashi, Fumiaki, Kobayashi, Norio, Sato, Akiko, Miyauchi, Naoko, Nishigori, Hidekazu, Mizuno, Satoshi, Sakurai, Kasumi, Ishikuro, Mami, Obara, Taku, Tatsuta, Nozomi, Nishijima, Ichiko, Fujiwara, Ikuma, Kuriyama, Shinichi, Metoki, Hirohito, Yaegashi, Nobuo, Nakai, Kunihiko, Arima, Takahiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387559/
https://www.ncbi.nlm.nih.gov/pubmed/30795788
http://dx.doi.org/10.1186/s12958-019-0471-1
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author Hattori, Hiromitsu
Kitamura, Akane
Takahashi, Fumiaki
Kobayashi, Norio
Sato, Akiko
Miyauchi, Naoko
Nishigori, Hidekazu
Mizuno, Satoshi
Sakurai, Kasumi
Ishikuro, Mami
Obara, Taku
Tatsuta, Nozomi
Nishijima, Ichiko
Fujiwara, Ikuma
Kuriyama, Shinichi
Metoki, Hirohito
Yaegashi, Nobuo
Nakai, Kunihiko
Arima, Takahiro
author_facet Hattori, Hiromitsu
Kitamura, Akane
Takahashi, Fumiaki
Kobayashi, Norio
Sato, Akiko
Miyauchi, Naoko
Nishigori, Hidekazu
Mizuno, Satoshi
Sakurai, Kasumi
Ishikuro, Mami
Obara, Taku
Tatsuta, Nozomi
Nishijima, Ichiko
Fujiwara, Ikuma
Kuriyama, Shinichi
Metoki, Hirohito
Yaegashi, Nobuo
Nakai, Kunihiko
Arima, Takahiro
author_sort Hattori, Hiromitsu
collection PubMed
description BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children’s Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001–1.198; MZT: AOR 4.229, 95% CI 2.614–6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12958-019-0471-1) contains supplementary material, which is available to authorized users.
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spelling pubmed-63875592019-03-04 The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study Hattori, Hiromitsu Kitamura, Akane Takahashi, Fumiaki Kobayashi, Norio Sato, Akiko Miyauchi, Naoko Nishigori, Hidekazu Mizuno, Satoshi Sakurai, Kasumi Ishikuro, Mami Obara, Taku Tatsuta, Nozomi Nishijima, Ichiko Fujiwara, Ikuma Kuriyama, Shinichi Metoki, Hirohito Yaegashi, Nobuo Nakai, Kunihiko Arima, Takahiro Reprod Biol Endocrinol Research BACKGROUND: Some studies have suggested that blastocyst transfer is associated with i) imbalance in the secondary sex ratio (SSR) (which favors male offspring), ii) increased incidence of monozygotic twins (MZT). In contrast, others have not found these changes. In this study, we evaluated the association between blastocyst transfer and SSR and MZT, considering potential parental confounders. METHODS: The Japan Environment and Children’s Study is a large, nationwide longitudinal birth cohort study funded by the Ministry of the Environment of Japan. We used this large dataset, including 103,099 pregnancies, to further investigate the association between blastocyst transfer, SSR and MZT, using spontaneously conceived pregnancies, non-assisted reproductive technology (non-ART) treatment (intrauterine insemination and ovulation induction with timed intercourse) and cleavage stage embryo transfer for comparison. We evaluated the association with each group, the SSR, and the frequency of MZT, calculating the adjusted odds ratio (AOR) using multivariable logistic regression analyses, adjusting for potential parental confounders such as basic health and socioeconomic status. RESULTS: For each group (spontaneous conception vs. non-ART treatment vs. cleavage stage embryo transfer vs. blastocyst transfer), the percentages of males were 51.3% vs 50.7% vs 48.9% vs 53.4% and the monozygotic twinning rates per pregnancy were 0.27% vs 0.11% vs 0.27% vs 0.99% respectively. Multivariate logistic regression analyses indicated that blastocyst transfer was significantly associated with a higher SSR and higher incidence of MZT than the other three groups (SSR: AOR 1.095, 95% CI1.001–1.198; MZT: AOR 4.229, 95% CI 2.614–6.684). CONCLUSIONS: There are significant relationships between blastocyst transfer and SSR imbalance and a higher occurrence of MZT. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12958-019-0471-1) contains supplementary material, which is available to authorized users. BioMed Central 2019-02-22 /pmc/articles/PMC6387559/ /pubmed/30795788 http://dx.doi.org/10.1186/s12958-019-0471-1 Text en © The Author(s). 2019 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research
Hattori, Hiromitsu
Kitamura, Akane
Takahashi, Fumiaki
Kobayashi, Norio
Sato, Akiko
Miyauchi, Naoko
Nishigori, Hidekazu
Mizuno, Satoshi
Sakurai, Kasumi
Ishikuro, Mami
Obara, Taku
Tatsuta, Nozomi
Nishijima, Ichiko
Fujiwara, Ikuma
Kuriyama, Shinichi
Metoki, Hirohito
Yaegashi, Nobuo
Nakai, Kunihiko
Arima, Takahiro
The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study
title The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study
title_full The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study
title_fullStr The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study
title_full_unstemmed The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study
title_short The risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the Japan Environment and Children’s Study
title_sort risk of secondary sex ratio imbalance and increased monozygotic twinning after blastocyst transfer: data from the japan environment and children’s study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387559/
https://www.ncbi.nlm.nih.gov/pubmed/30795788
http://dx.doi.org/10.1186/s12958-019-0471-1
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