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Evaluation of pharmacokinetics and pharmacodynamics of sinomeninehyaluronic acid conjugate after intraarticular administration for osteoarthritis treatment

OBJECTIVES: Intra-articular injection of sinomenine (SN) is an effective treatment method for knee osteoarthritis (OA), however, SN could be eliminated quickly in vivo. To extend the residence time of SN in the joint cavity, the SN-hyaluronic acid (HA) conjugate was prepared previously. This study w...

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Detalles Bibliográficos
Autores principales:	Liu, Jie, Shao, Huarong, Fang, Shaoying, Cheng, Yanling, Ling, Peixue, Chen, Jianying
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2019
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387601/ https://www.ncbi.nlm.nih.gov/pubmed/30858696 http://dx.doi.org/10.2147/DDDT.S186558

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