Acute silencing of hippocampal CA3 reveals a dominant role in place field responses

Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased response...

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Detalles Bibliográficos
Autores principales: Davoudi, Heydar, Foster, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387637/
https://www.ncbi.nlm.nih.gov/pubmed/30664772
http://dx.doi.org/10.1038/s41593-018-0321-z
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author Davoudi, Heydar
Foster, David J.
author_facet Davoudi, Heydar
Foster, David J.
author_sort Davoudi, Heydar
collection PubMed
description Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased responses. These results imply that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealing heterogeneity in input dominance across cells.
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spelling pubmed-63876372019-07-21 Acute silencing of hippocampal CA3 reveals a dominant role in place field responses Davoudi, Heydar Foster, David J. Nat Neurosci Article Neurons in hippocampal output area CA1 are thought to exhibit redundancy across cortical and hippocampal inputs. Here we show instead that acute silencing of CA3 terminals drastically reduces place field responses for many CA1 neurons, while a smaller number are unaffected or have increased responses. These results imply that CA3 is the predominant driver of CA1 place cells under normal conditions, while also revealing heterogeneity in input dominance across cells. 2019-01-21 2019-03 /pmc/articles/PMC6387637/ /pubmed/30664772 http://dx.doi.org/10.1038/s41593-018-0321-z Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Davoudi, Heydar
Foster, David J.
Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
title Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
title_full Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
title_fullStr Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
title_full_unstemmed Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
title_short Acute silencing of hippocampal CA3 reveals a dominant role in place field responses
title_sort acute silencing of hippocampal ca3 reveals a dominant role in place field responses
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387637/
https://www.ncbi.nlm.nih.gov/pubmed/30664772
http://dx.doi.org/10.1038/s41593-018-0321-z
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