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Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses
The term neglected diseases refers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. Th...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387720/ https://www.ncbi.nlm.nih.gov/pubmed/30881596 http://dx.doi.org/10.1155/2019/6587150 |
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author | Luna, Emanuela Coutinho Luna, Isadora Silva Scotti, Luciana Monteiro, Alex France M. Scotti, Marcus Tullius de Moura, Ricardo Olímpio de Araújo, Rodrigo Santos Aquino Monteiro, Kadja Luana Chagas de Aquino, Thiago Mendonça Ribeiro, Frederico Fávaro Mendonça, Francisco Jaime Bezerra |
author_facet | Luna, Emanuela Coutinho Luna, Isadora Silva Scotti, Luciana Monteiro, Alex France M. Scotti, Marcus Tullius de Moura, Ricardo Olímpio de Araújo, Rodrigo Santos Aquino Monteiro, Kadja Luana Chagas de Aquino, Thiago Mendonça Ribeiro, Frederico Fávaro Mendonça, Francisco Jaime Bezerra |
author_sort | Luna, Emanuela Coutinho |
collection | PubMed |
description | The term neglected diseases refers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. The fact that these diseases were historically not considered priorities for pharmaceutical companies made the available treatments options obsolete, precarious, outdated, and in some cases nonexistent. The use of plants for medicinal, religious, and cosmetic purposes has a history dating back to the emergence of humanity. One of the principal fractions of chemical substances found in plants are essential oils (EOs). EOs consist of a mixture of volatile and hydrophobic secondary metabolites with marked odors, composed primarily of terpenes and phenylpropanoids. They have great commercial value and were widely used in traditional medicine, by phytotherapy practitioners, and in public health services for the treatment of several conditions, including neglected diseases. In addition to the recognized cytoprotective and antioxidative activities of many of these compounds, larvicidal, insecticidal, and antiparasitic activities have been associated with the induction of oxidative stress in parasites, increasing levels of nitric oxide in the infected host, reducing parasite resistance to reactive oxygen species, and increasing lipid peroxidation, ultimately leading to serious damage to cell membranes. The hydrophobicity of these compounds also allows them to cross the membranes of parasites as well as the blood-brain barrier, collaborating in combat at the second stage of several of these infections. Based on these considerations, the aim of this review was to present an update of the potential of EOs, their fractions, and their chemical constituents, against some neglected diseases, including American and African trypanosomiasis, leishmaniasis, and arboviruses, specially dengue. |
format | Online Article Text |
id | pubmed-6387720 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-63877202019-03-17 Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses Luna, Emanuela Coutinho Luna, Isadora Silva Scotti, Luciana Monteiro, Alex France M. Scotti, Marcus Tullius de Moura, Ricardo Olímpio de Araújo, Rodrigo Santos Aquino Monteiro, Kadja Luana Chagas de Aquino, Thiago Mendonça Ribeiro, Frederico Fávaro Mendonça, Francisco Jaime Bezerra Oxid Med Cell Longev Review Article The term neglected diseases refers to a group of infections caused by various classes of pathogens, including protozoa, viruses, bacteria, and helminths, most often affecting impoverished populations without adequate sanitation living in close contact with infectious vectors and domestic animals. The fact that these diseases were historically not considered priorities for pharmaceutical companies made the available treatments options obsolete, precarious, outdated, and in some cases nonexistent. The use of plants for medicinal, religious, and cosmetic purposes has a history dating back to the emergence of humanity. One of the principal fractions of chemical substances found in plants are essential oils (EOs). EOs consist of a mixture of volatile and hydrophobic secondary metabolites with marked odors, composed primarily of terpenes and phenylpropanoids. They have great commercial value and were widely used in traditional medicine, by phytotherapy practitioners, and in public health services for the treatment of several conditions, including neglected diseases. In addition to the recognized cytoprotective and antioxidative activities of many of these compounds, larvicidal, insecticidal, and antiparasitic activities have been associated with the induction of oxidative stress in parasites, increasing levels of nitric oxide in the infected host, reducing parasite resistance to reactive oxygen species, and increasing lipid peroxidation, ultimately leading to serious damage to cell membranes. The hydrophobicity of these compounds also allows them to cross the membranes of parasites as well as the blood-brain barrier, collaborating in combat at the second stage of several of these infections. Based on these considerations, the aim of this review was to present an update of the potential of EOs, their fractions, and their chemical constituents, against some neglected diseases, including American and African trypanosomiasis, leishmaniasis, and arboviruses, specially dengue. Hindawi 2019-02-07 /pmc/articles/PMC6387720/ /pubmed/30881596 http://dx.doi.org/10.1155/2019/6587150 Text en Copyright © 2019 Emanuela Coutinho Luna et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Luna, Emanuela Coutinho Luna, Isadora Silva Scotti, Luciana Monteiro, Alex France M. Scotti, Marcus Tullius de Moura, Ricardo Olímpio de Araújo, Rodrigo Santos Aquino Monteiro, Kadja Luana Chagas de Aquino, Thiago Mendonça Ribeiro, Frederico Fávaro Mendonça, Francisco Jaime Bezerra Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses |
title | Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses |
title_full | Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses |
title_fullStr | Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses |
title_full_unstemmed | Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses |
title_short | Active Essential Oils and Their Components in Use against Neglected Diseases and Arboviruses |
title_sort | active essential oils and their components in use against neglected diseases and arboviruses |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387720/ https://www.ncbi.nlm.nih.gov/pubmed/30881596 http://dx.doi.org/10.1155/2019/6587150 |
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