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Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis

Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and N...

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Autores principales: Lee, Yong-ho, Cho, Yongin, Lee, Byung-Wan, Park, Cheol-Young, Lee, Dae Ho, Cha, Bong-Soo, Rhee, Eun-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Diabetes Association 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387876/
https://www.ncbi.nlm.nih.gov/pubmed/30793550
http://dx.doi.org/10.4093/dmj.2019.0011
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author Lee, Yong-ho
Cho, Yongin
Lee, Byung-Wan
Park, Cheol-Young
Lee, Dae Ho
Cha, Bong-Soo
Rhee, Eun-Jung
author_facet Lee, Yong-ho
Cho, Yongin
Lee, Byung-Wan
Park, Cheol-Young
Lee, Dae Ho
Cha, Bong-Soo
Rhee, Eun-Jung
author_sort Lee, Yong-ho
collection PubMed
description Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis.
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spelling pubmed-63878762019-03-04 Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis Lee, Yong-ho Cho, Yongin Lee, Byung-Wan Park, Cheol-Young Lee, Dae Ho Cha, Bong-Soo Rhee, Eun-Jung Diabetes Metab J Review Nonalcoholic fatty liver disease (NAFLD) and diabetes are common metabolic disorders whose prevalence rates are expected to rise worldwide, corresponding to aging and increasingly obese populations. Compared to the general population (around 25%), 50% to 70% of people with diabetes have NAFLD, and NAFLD severity (including fibrosis) tends to be worsened by the presence of diabetes. NAFLD is considered an emerging risk factor for type 2 diabetes mellitus and a contributor to the development of chronic diabetes-related complications. This reciprocal relationship demonstrates the importance of confirming suspected NAFLD in patients with diabetes. Due to the invasive nature of liver biopsy to assess NAFLD status, various alternative non-invasive modalities have been developed and validated. Here, we summarized the epidemiology of NAFLD in patients with diabetes and reviewed currently available imaging modalities and biomarker-based prediction models for their ability to detect liver steatosis and/or fibrosis. Korean Diabetes Association 2019-02 2018-12-17 /pmc/articles/PMC6387876/ /pubmed/30793550 http://dx.doi.org/10.4093/dmj.2019.0011 Text en Copyright © 2019 Korean Diabetes Association http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Lee, Yong-ho
Cho, Yongin
Lee, Byung-Wan
Park, Cheol-Young
Lee, Dae Ho
Cha, Bong-Soo
Rhee, Eun-Jung
Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
title Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
title_full Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
title_fullStr Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
title_full_unstemmed Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
title_short Nonalcoholic Fatty Liver Disease in Diabetes. Part I: Epidemiology and Diagnosis
title_sort nonalcoholic fatty liver disease in diabetes. part i: epidemiology and diagnosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6387876/
https://www.ncbi.nlm.nih.gov/pubmed/30793550
http://dx.doi.org/10.4093/dmj.2019.0011
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