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Role of the Choroid in Age-related Macular Degeneration: A Current Review
Age-related macular degeneration (AMD) is a major cause of vision loss in the developed world and its pathogenesis is a topic of active research. To date, much study has been focused on the role of the retinal pigment epithelium (RPE) and Bruch's membrane (BrM) in AMD pathogenesis, but the role...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Medknow Publications & Media Pvt Ltd
2019
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388521/ https://www.ncbi.nlm.nih.gov/pubmed/30820291 http://dx.doi.org/10.4103/jovr.jovr_125_18 |
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author | Farazdaghi, Marybeth K. Ebrahimi, Katayoon B. |
author_facet | Farazdaghi, Marybeth K. Ebrahimi, Katayoon B. |
author_sort | Farazdaghi, Marybeth K. |
collection | PubMed |
description | Age-related macular degeneration (AMD) is a major cause of vision loss in the developed world and its pathogenesis is a topic of active research. To date, much study has been focused on the role of the retinal pigment epithelium (RPE) and Bruch's membrane (BrM) in AMD pathogenesis, but the role of the choroid has also been investigated. In this review, we focus on recent advancements in research in the role of the choroid in AMD, beginning with an exploration of the histopathologic, cellular and molecular changes that occur in the choroid in AMD and concluding by discussing new choroidal imaging techniques and patterns seen on fluorescein angiography, indocyanine green angiography, spectral-domain optical coherence tomography and optical coherence tomography angiography. Exploring these domains will lead to a better understanding of the factors at play beyond the outer retina in this important disease. |
format | Online Article Text |
id | pubmed-6388521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Medknow Publications & Media Pvt Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-63885212019-02-28 Role of the Choroid in Age-related Macular Degeneration: A Current Review Farazdaghi, Marybeth K. Ebrahimi, Katayoon B. J Ophthalmic Vis Res Review Article Age-related macular degeneration (AMD) is a major cause of vision loss in the developed world and its pathogenesis is a topic of active research. To date, much study has been focused on the role of the retinal pigment epithelium (RPE) and Bruch's membrane (BrM) in AMD pathogenesis, but the role of the choroid has also been investigated. In this review, we focus on recent advancements in research in the role of the choroid in AMD, beginning with an exploration of the histopathologic, cellular and molecular changes that occur in the choroid in AMD and concluding by discussing new choroidal imaging techniques and patterns seen on fluorescein angiography, indocyanine green angiography, spectral-domain optical coherence tomography and optical coherence tomography angiography. Exploring these domains will lead to a better understanding of the factors at play beyond the outer retina in this important disease. Medknow Publications & Media Pvt Ltd 2019 /pmc/articles/PMC6388521/ /pubmed/30820291 http://dx.doi.org/10.4103/jovr.jovr_125_18 Text en Copyright: © 2019 Journal of Ophthalmic and Vision Research http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Review Article Farazdaghi, Marybeth K. Ebrahimi, Katayoon B. Role of the Choroid in Age-related Macular Degeneration: A Current Review |
title | Role of the Choroid in Age-related Macular Degeneration: A Current Review |
title_full | Role of the Choroid in Age-related Macular Degeneration: A Current Review |
title_fullStr | Role of the Choroid in Age-related Macular Degeneration: A Current Review |
title_full_unstemmed | Role of the Choroid in Age-related Macular Degeneration: A Current Review |
title_short | Role of the Choroid in Age-related Macular Degeneration: A Current Review |
title_sort | role of the choroid in age-related macular degeneration: a current review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388521/ https://www.ncbi.nlm.nih.gov/pubmed/30820291 http://dx.doi.org/10.4103/jovr.jovr_125_18 |
work_keys_str_mv | AT farazdaghimarybethk roleofthechoroidinagerelatedmaculardegenerationacurrentreview AT ebrahimikatayoonb roleofthechoroidinagerelatedmaculardegenerationacurrentreview |