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Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging

Cerebral palsy (CP) is associated with movement disorders and reduced muscle size. This latter phenomenon has been observed by computing muscle volumes from conventional MRI, with most studies reporting significantly reduced volumes in leg muscles. This indicates impaired muscle growth, but without...

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Autores principales: Sahrmann, Annika S., Stott, Ngaire Susan, Besier, Thor F., Fernandez, Justin W., Handsfield, Geoffrey G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388915/
https://www.ncbi.nlm.nih.gov/pubmed/30802250
http://dx.doi.org/10.1371/journal.pone.0205944
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author Sahrmann, Annika S.
Stott, Ngaire Susan
Besier, Thor F.
Fernandez, Justin W.
Handsfield, Geoffrey G.
author_facet Sahrmann, Annika S.
Stott, Ngaire Susan
Besier, Thor F.
Fernandez, Justin W.
Handsfield, Geoffrey G.
author_sort Sahrmann, Annika S.
collection PubMed
description Cerebral palsy (CP) is associated with movement disorders and reduced muscle size. This latter phenomenon has been observed by computing muscle volumes from conventional MRI, with most studies reporting significantly reduced volumes in leg muscles. This indicates impaired muscle growth, but without knowing muscle fiber orientation, it is not clear whether muscle growth in CP is impaired in the along-fiber direction (indicating shortened muscles and limited range of motion) or the cross-fiber direction (indicating weak muscles and impaired strength). Using Diffusion Tensor Imaging (DTI) we can determine muscle fiber orientation and construct 3D muscle architectures which can be used to examine both along-fiber length and cross-sectional area. Such an approach has not been undertaken in CP. Here, we use advanced DTI sequences with fast imaging times to capture fiber orientations in the soleus muscle of children with CP and age-matched, able-bodied controls. Cross sectional areas perpendicular to the muscle fiber direction were reduced (37 ± 11%) in children with CP compared to controls, indicating impaired muscle strength. Along-fiber muscle lengths were not different between groups. This study is the first to demonstrate along-fiber and cross-fiber muscle architecture in CP using DTI and implicates impaired cross-sectional muscle growth in children with cerebral palsy.
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spelling pubmed-63889152019-03-08 Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging Sahrmann, Annika S. Stott, Ngaire Susan Besier, Thor F. Fernandez, Justin W. Handsfield, Geoffrey G. PLoS One Research Article Cerebral palsy (CP) is associated with movement disorders and reduced muscle size. This latter phenomenon has been observed by computing muscle volumes from conventional MRI, with most studies reporting significantly reduced volumes in leg muscles. This indicates impaired muscle growth, but without knowing muscle fiber orientation, it is not clear whether muscle growth in CP is impaired in the along-fiber direction (indicating shortened muscles and limited range of motion) or the cross-fiber direction (indicating weak muscles and impaired strength). Using Diffusion Tensor Imaging (DTI) we can determine muscle fiber orientation and construct 3D muscle architectures which can be used to examine both along-fiber length and cross-sectional area. Such an approach has not been undertaken in CP. Here, we use advanced DTI sequences with fast imaging times to capture fiber orientations in the soleus muscle of children with CP and age-matched, able-bodied controls. Cross sectional areas perpendicular to the muscle fiber direction were reduced (37 ± 11%) in children with CP compared to controls, indicating impaired muscle strength. Along-fiber muscle lengths were not different between groups. This study is the first to demonstrate along-fiber and cross-fiber muscle architecture in CP using DTI and implicates impaired cross-sectional muscle growth in children with cerebral palsy. Public Library of Science 2019-02-25 /pmc/articles/PMC6388915/ /pubmed/30802250 http://dx.doi.org/10.1371/journal.pone.0205944 Text en © 2019 Sahrmann et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Sahrmann, Annika S.
Stott, Ngaire Susan
Besier, Thor F.
Fernandez, Justin W.
Handsfield, Geoffrey G.
Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging
title Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging
title_full Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging
title_fullStr Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging
title_full_unstemmed Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging
title_short Soleus muscle weakness in cerebral palsy: Muscle architecture revealed with Diffusion Tensor Imaging
title_sort soleus muscle weakness in cerebral palsy: muscle architecture revealed with diffusion tensor imaging
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388915/
https://www.ncbi.nlm.nih.gov/pubmed/30802250
http://dx.doi.org/10.1371/journal.pone.0205944
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