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Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report
Merkel cell carcinoma (MCC) is a rare, aggressive skin malignancy that has a propensity for local recurrence and metastasis to the lymph nodes. In this case report, we discuss a 54-year-old female with rheumatoid arthritis (RA) who had received treatment with prednisone (15 mg/day) for symptom relie...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388979/ https://www.ncbi.nlm.nih.gov/pubmed/30863106 http://dx.doi.org/10.2147/OTT.S188403 |
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author | Li, Na Wang, Guodong Jiang, Xiaohong Huang, Minguang Tian, Huanyong Xuan, Feng Zhang, Yufeng Lv, Yanting Hu, Mengjun Wang, Zhen Ren, Peng Xu, Maoyi |
author_facet | Li, Na Wang, Guodong Jiang, Xiaohong Huang, Minguang Tian, Huanyong Xuan, Feng Zhang, Yufeng Lv, Yanting Hu, Mengjun Wang, Zhen Ren, Peng Xu, Maoyi |
author_sort | Li, Na |
collection | PubMed |
description | Merkel cell carcinoma (MCC) is a rare, aggressive skin malignancy that has a propensity for local recurrence and metastasis to the lymph nodes. In this case report, we discuss a 54-year-old female with rheumatoid arthritis (RA) who had received treatment with prednisone (15 mg/day) for symptom relief and management. The patient visited our hospital with complaints of a nodule in right preauricular area. Computed tomography (CT) scans revealed no distant metastasis. The patient underwent surgical resection and histopathological evaluation of the nodule led to the diagnosis of MCC. The patients received post-surgical treatment with 6 MeV electronic wire radiotherapy. Six months later, CT of the head, neck, abdomen and chest demonstrated a right cervical lymph node mass at the C2 level. The patient then underwent cervical lymph node biopsy and pathological diagnosis confirmed metastatic MCC. One month after the lymph node biopsy, the patients received postoperative intensity modulated radiation therapy in the biopsied area. The patient did not experience any adverse effects to the therapy. In conclusion, the MCC patients with RA can tolerate radiation therapy. As MCC is a highly malignant neoplasia, considering the immune checkpoint inhibitors can lead to immune-related adverse events, detection of MCC at earlier stages is associated with better survival. The treatment decisions of MCC patients with RA continues is still challenging. |
format | Online Article Text |
id | pubmed-6388979 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63889792019-03-12 Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report Li, Na Wang, Guodong Jiang, Xiaohong Huang, Minguang Tian, Huanyong Xuan, Feng Zhang, Yufeng Lv, Yanting Hu, Mengjun Wang, Zhen Ren, Peng Xu, Maoyi Onco Targets Ther Case Report Merkel cell carcinoma (MCC) is a rare, aggressive skin malignancy that has a propensity for local recurrence and metastasis to the lymph nodes. In this case report, we discuss a 54-year-old female with rheumatoid arthritis (RA) who had received treatment with prednisone (15 mg/day) for symptom relief and management. The patient visited our hospital with complaints of a nodule in right preauricular area. Computed tomography (CT) scans revealed no distant metastasis. The patient underwent surgical resection and histopathological evaluation of the nodule led to the diagnosis of MCC. The patients received post-surgical treatment with 6 MeV electronic wire radiotherapy. Six months later, CT of the head, neck, abdomen and chest demonstrated a right cervical lymph node mass at the C2 level. The patient then underwent cervical lymph node biopsy and pathological diagnosis confirmed metastatic MCC. One month after the lymph node biopsy, the patients received postoperative intensity modulated radiation therapy in the biopsied area. The patient did not experience any adverse effects to the therapy. In conclusion, the MCC patients with RA can tolerate radiation therapy. As MCC is a highly malignant neoplasia, considering the immune checkpoint inhibitors can lead to immune-related adverse events, detection of MCC at earlier stages is associated with better survival. The treatment decisions of MCC patients with RA continues is still challenging. Dove Medical Press 2019-02-19 /pmc/articles/PMC6388979/ /pubmed/30863106 http://dx.doi.org/10.2147/OTT.S188403 Text en © 2019 Li et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Case Report Li, Na Wang, Guodong Jiang, Xiaohong Huang, Minguang Tian, Huanyong Xuan, Feng Zhang, Yufeng Lv, Yanting Hu, Mengjun Wang, Zhen Ren, Peng Xu, Maoyi Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
title | Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
title_full | Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
title_fullStr | Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
title_full_unstemmed | Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
title_short | Merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
title_sort | merkel cell carcinoma metastatic to cervical lymph node in a patient with rheumatoid arthritis: a case report |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6388979/ https://www.ncbi.nlm.nih.gov/pubmed/30863106 http://dx.doi.org/10.2147/OTT.S188403 |
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