Knockdown of EIF3C promotes human U-2OS cells apoptosis through increased CASP3/7 and Chk1/2 by upregulating SAPK/JNK

BACKGROUND: As a component of the EIF3 complex, EIF3C is essential for several steps in protein synthesis initiation. Recently, it has been addressed that EIF3C is overexpressed in several human cancers and plays a pivotal role in cell proliferation and tumorigenesis. MATERIALS AND METHODS: Immunohi...

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Detalles Bibliográficos
Autores principales: Gao, Weilu, Hu, Yong, Zhang, Zhengqin, Du, Gongwen, Yin, Li, Yin, Zongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389005/
https://www.ncbi.nlm.nih.gov/pubmed/30863090
http://dx.doi.org/10.2147/OTT.S187209

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389005/
https://www.ncbi.nlm.nih.gov/pubmed/30863090
http://dx.doi.org/10.2147/OTT.S187209

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