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Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects
Trametes robiniophila Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Dove Medical Press
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389013/ https://www.ncbi.nlm.nih.gov/pubmed/30863164 http://dx.doi.org/10.2147/CMAR.S193174 |
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author | Pan, Jun Yang, Chenghui Jiang, Zhou Huang, Jian |
author_facet | Pan, Jun Yang, Chenghui Jiang, Zhou Huang, Jian |
author_sort | Pan, Jun |
collection | PubMed |
description | Trametes robiniophila Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the indirect effects on immune cells. In vitro and in vivo experiment showed Huaier directly inhibited tumor cell proliferation, induced tumor cell death, prevented metastasis and interfered with angiogenesis via various signaling pathways. The immunomodulatory effect of Huaier is associated with enhancement of the number and function of CD4(+) T cells and NK cells, regulation of the polarization and function of macrophages, and elevated secretion of immune stimulatory cytokines. In this review, the anti-cancer effects and combined treatments of Huaier with other anti-cancer therapies, and the underlying mechanisms are summarized and discussed. |
format | Online Article Text |
id | pubmed-6389013 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-63890132019-03-12 Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects Pan, Jun Yang, Chenghui Jiang, Zhou Huang, Jian Cancer Manag Res Review Trametes robiniophila Murr also known as Huaier, one of the traditional Chinese medicines, has been shown an effective adjuvant of cancer therapy. Accumulating evidence suggests that the anti-cancer effects of Huaier can be briefly divided into two aspects: the direct effects on tumor cells and the indirect effects on immune cells. In vitro and in vivo experiment showed Huaier directly inhibited tumor cell proliferation, induced tumor cell death, prevented metastasis and interfered with angiogenesis via various signaling pathways. The immunomodulatory effect of Huaier is associated with enhancement of the number and function of CD4(+) T cells and NK cells, regulation of the polarization and function of macrophages, and elevated secretion of immune stimulatory cytokines. In this review, the anti-cancer effects and combined treatments of Huaier with other anti-cancer therapies, and the underlying mechanisms are summarized and discussed. Dove Medical Press 2019-02-14 /pmc/articles/PMC6389013/ /pubmed/30863164 http://dx.doi.org/10.2147/CMAR.S193174 Text en © 2019 Pan et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Review Pan, Jun Yang, Chenghui Jiang, Zhou Huang, Jian Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects |
title | Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects |
title_full | Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects |
title_fullStr | Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects |
title_full_unstemmed | Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects |
title_short | Trametes robiniophila Murr: a traditional Chinese medicine with potent anti-tumor effects |
title_sort | trametes robiniophila murr: a traditional chinese medicine with potent anti-tumor effects |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389013/ https://www.ncbi.nlm.nih.gov/pubmed/30863164 http://dx.doi.org/10.2147/CMAR.S193174 |
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