A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil

Therapy-related acute myeloid leukemia (t-AML) is most frequently observed after the use of alkylating agents and topoisomerase II inhibitors and is associated with the frequent occurrence of high-risk karyotypes, poor prognosis, and distinct clinical behavior. Therefore, identifying therapy-related...

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Autores principales: Pinczés, László, Molnár, Sarolta, Telek, Béla, Illés, Árpád
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2018
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389024/
https://www.ncbi.nlm.nih.gov/pubmed/30820388
http://dx.doi.org/10.7759/cureus.3769
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author Pinczés, László
Molnár, Sarolta
Telek, Béla
Illés, Árpád
author_facet Pinczés, László
Molnár, Sarolta
Telek, Béla
Illés, Árpád
author_sort Pinczés, László
collection PubMed
description Therapy-related acute myeloid leukemia (t-AML) is most frequently observed after the use of alkylating agents and topoisomerase II inhibitors and is associated with the frequent occurrence of high-risk karyotypes, poor prognosis, and distinct clinical behavior. Therefore, identifying therapy-related causation among patients with newly diagnosed acute leukemia is of great interest. We report the case of a patient who developed therapy-related acute myeloid leukemia after exposure to antimetabolite chemotherapy and emphasize the importance of identifying genetic alterations when the possibility of a therapy-related origin arises.
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spelling pubmed-63890242019-02-28 A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil Pinczés, László Molnár, Sarolta Telek, Béla Illés, Árpád Cureus Internal Medicine Therapy-related acute myeloid leukemia (t-AML) is most frequently observed after the use of alkylating agents and topoisomerase II inhibitors and is associated with the frequent occurrence of high-risk karyotypes, poor prognosis, and distinct clinical behavior. Therefore, identifying therapy-related causation among patients with newly diagnosed acute leukemia is of great interest. We report the case of a patient who developed therapy-related acute myeloid leukemia after exposure to antimetabolite chemotherapy and emphasize the importance of identifying genetic alterations when the possibility of a therapy-related origin arises. Cureus 2018-12-24 /pmc/articles/PMC6389024/ /pubmed/30820388 http://dx.doi.org/10.7759/cureus.3769 Text en Copyright © 2018, Pinczés et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Pinczés, László
Molnár, Sarolta
Telek, Béla
Illés, Árpád
A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil
title A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil
title_full A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil
title_fullStr A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil
title_full_unstemmed A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil
title_short A Case of Therapy-related Acute Myeloid Leukemia Following Treatment with 5-Fluorouracil
title_sort case of therapy-related acute myeloid leukemia following treatment with 5-fluorouracil
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389024/
https://www.ncbi.nlm.nih.gov/pubmed/30820388
http://dx.doi.org/10.7759/cureus.3769
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