Cargando…

A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan

BACKGROUND: Approximately 10 million people in Pakistan are infected with the hepatitis C virus (HCV). Most patients develop chronic hepatitis, with rare cases of spontaneous clearance. However, little is known about multidrug resistant viral variants in Pakistan. FINDINGS: This case study describes...

Descripción completa

Detalles Bibliográficos
Autores principales: Zia, Asad, Ali, Muhammad, Aziz, Hafsa, Zia, Muhammad, Shinwari, Zabta Khan, Raza, Abida
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389057/
https://www.ncbi.nlm.nih.gov/pubmed/29429413
http://dx.doi.org/10.1186/s40249-018-0386-7
_version_ 1783397877836414976
author Zia, Asad
Ali, Muhammad
Aziz, Hafsa
Zia, Muhammad
Shinwari, Zabta Khan
Raza, Abida
author_facet Zia, Asad
Ali, Muhammad
Aziz, Hafsa
Zia, Muhammad
Shinwari, Zabta Khan
Raza, Abida
author_sort Zia, Asad
collection PubMed
description BACKGROUND: Approximately 10 million people in Pakistan are infected with the hepatitis C virus (HCV). Most patients develop chronic hepatitis, with rare cases of spontaneous clearance. However, little is known about multidrug resistant viral variants in Pakistan. FINDINGS: This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in 2003. After an initial diagnosis of viral infection, the patient remained treatment naïve for 5 years. He received two therapy cycles of interferon (IFN) plus ribavirin (RBV) in 2007 and 2010, however, he was non-responsive to the therapy. The patient then received an additional two treatment cycles of pegylated IFN α-2b plus RBV (in 2011 and 2013); he was still non-responsive. In 2016, the patient underwent sofosbuvir plus RBV combination therapy, however, the sustained virological response was still not achieved. The host genetic factor was found to be heterozygous guanine and thymine (GT) and cytosine and thymine (CT) genotypes of rs8099917 and rs12979860 polymorphism of IL28B, respectively. Phylogenetic analysis suggests that the resistant variant belong to an out-group and may require triple therapy. CONCLUSIONS: This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in Pakistan. Further studies are needed to understand multidrug-resistant HCV variants in the Pakistani population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40249-018-0386-7) contains supplementary material, which is available to authorized users.
format Online
Article
Text
id pubmed-6389057
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-63890572019-03-19 A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan Zia, Asad Ali, Muhammad Aziz, Hafsa Zia, Muhammad Shinwari, Zabta Khan Raza, Abida Infect Dis Poverty Case Study BACKGROUND: Approximately 10 million people in Pakistan are infected with the hepatitis C virus (HCV). Most patients develop chronic hepatitis, with rare cases of spontaneous clearance. However, little is known about multidrug resistant viral variants in Pakistan. FINDINGS: This case study describes a 47-year-old male diagnosed with chronic HCV genotype 3a infection in 2003. After an initial diagnosis of viral infection, the patient remained treatment naïve for 5 years. He received two therapy cycles of interferon (IFN) plus ribavirin (RBV) in 2007 and 2010, however, he was non-responsive to the therapy. The patient then received an additional two treatment cycles of pegylated IFN α-2b plus RBV (in 2011 and 2013); he was still non-responsive. In 2016, the patient underwent sofosbuvir plus RBV combination therapy, however, the sustained virological response was still not achieved. The host genetic factor was found to be heterozygous guanine and thymine (GT) and cytosine and thymine (CT) genotypes of rs8099917 and rs12979860 polymorphism of IL28B, respectively. Phylogenetic analysis suggests that the resistant variant belong to an out-group and may require triple therapy. CONCLUSIONS: This is the first case that reports on a HCV-infected individual who was a non-responder to multiple IFN therapies in Pakistan. Further studies are needed to understand multidrug-resistant HCV variants in the Pakistani population. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s40249-018-0386-7) contains supplementary material, which is available to authorized users. BioMed Central 2018-02-11 /pmc/articles/PMC6389057/ /pubmed/29429413 http://dx.doi.org/10.1186/s40249-018-0386-7 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Study
Zia, Asad
Ali, Muhammad
Aziz, Hafsa
Zia, Muhammad
Shinwari, Zabta Khan
Raza, Abida
A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
title A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
title_full A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
title_fullStr A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
title_full_unstemmed A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
title_short A case of a patient infected with a hepatitis C virus genotype 3a multidrug resistant variant in Pakistan
title_sort case of a patient infected with a hepatitis c virus genotype 3a multidrug resistant variant in pakistan
topic Case Study
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389057/
https://www.ncbi.nlm.nih.gov/pubmed/29429413
http://dx.doi.org/10.1186/s40249-018-0386-7
work_keys_str_mv AT ziaasad acaseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT alimuhammad acaseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT azizhafsa acaseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT ziamuhammad acaseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT shinwarizabtakhan acaseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT razaabida acaseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT ziaasad caseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT alimuhammad caseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT azizhafsa caseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT ziamuhammad caseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT shinwarizabtakhan caseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan
AT razaabida caseofapatientinfectedwithahepatitiscvirusgenotype3amultidrugresistantvariantinpakistan