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Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013

BACKGROUND: Unintended pregnancy is a persistent and global issue with consequences for the health and well-being of mothers and babies. The aim of this paper is to examine unintended pregnancy over time in the context of substantial human immunodeficiency virus (HIV) prevalence and increasing acces...

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Autores principales: Grilo, Stephanie Ann, Song, Xiaoyu, Lutalo, Tom, Mullinax, Margo, Mathur, Sanyukta, Santelli, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389071/
https://www.ncbi.nlm.nih.gov/pubmed/29486752
http://dx.doi.org/10.1186/s12905-018-0535-y
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author Grilo, Stephanie Ann
Song, Xiaoyu
Lutalo, Tom
Mullinax, Margo
Mathur, Sanyukta
Santelli, John
author_facet Grilo, Stephanie Ann
Song, Xiaoyu
Lutalo, Tom
Mullinax, Margo
Mathur, Sanyukta
Santelli, John
author_sort Grilo, Stephanie Ann
collection PubMed
description BACKGROUND: Unintended pregnancy is a persistent and global issue with consequences for the health and well-being of mothers and babies. The aim of this paper is to examine unintended pregnancy over time in the context of substantial human immunodeficiency virus (HIV) prevalence and increasing access to anti-retro viral therapy (ART). METHOD: Data are from the Rakai Community Cohort Study (RCCS) – a cohort of communities with 10,000–12,000 adults, ages 15–49, in Rakai District, Uganda. We examined prevalence of current pregnancies over time, intended pregnancy, and unintended pregnancies (unwanted, mistimed, ambivalent). We then examined risk factors for the different categories of unintended pregnancy among women who were currently pregnant. The full sample included 32,205 observations over 13 years. RESULTS: The prevalence of mistimed pregnancy and unwanted pregnancy both decreased significantly over time (p < .001). The prevalence of current pregnancies and intended pregnancy showed no significant changes over the thirteen year period. The same overall pattern was found when only examining HIV positive women in the sample; however, the trends were not significant. Out of the 2820 current pregnancies reported, 54.4% were intended, 29.8% were mistimed, 13.2% were unwanted, and 2.5% were ambivalent. After controlling for other predictors, HIV status had no independent effect on mistimed pregnancy but had a significant effect on unwanted pregnancy (RRR = 2.44, 95% CI = 1.65–3.61, p < .001] and ambivalent pregnancy [RRR = 2.07; CI: 1.03 to 4.18, p = 0.041]. In 2004, after the introduction of ART, there was a decreased risk in unintended pregnancy [RR = 0.75; CI: 0.66 to 0.84, p < .001]. Women with a secondary education or higher also had a decreased risk in unintended pregnancy [RR = 0.70; CI: 0.70 to 0.92, p = 0.002]. DISCUSSION: HIV was an important predictor of unwanted pregnancy. Unintended pregnancy decreased in the sample over time which may be due to an increase in ART availability and rising levels of education.
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spelling pubmed-63890712019-03-19 Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013 Grilo, Stephanie Ann Song, Xiaoyu Lutalo, Tom Mullinax, Margo Mathur, Sanyukta Santelli, John BMC Womens Health Research Article BACKGROUND: Unintended pregnancy is a persistent and global issue with consequences for the health and well-being of mothers and babies. The aim of this paper is to examine unintended pregnancy over time in the context of substantial human immunodeficiency virus (HIV) prevalence and increasing access to anti-retro viral therapy (ART). METHOD: Data are from the Rakai Community Cohort Study (RCCS) – a cohort of communities with 10,000–12,000 adults, ages 15–49, in Rakai District, Uganda. We examined prevalence of current pregnancies over time, intended pregnancy, and unintended pregnancies (unwanted, mistimed, ambivalent). We then examined risk factors for the different categories of unintended pregnancy among women who were currently pregnant. The full sample included 32,205 observations over 13 years. RESULTS: The prevalence of mistimed pregnancy and unwanted pregnancy both decreased significantly over time (p < .001). The prevalence of current pregnancies and intended pregnancy showed no significant changes over the thirteen year period. The same overall pattern was found when only examining HIV positive women in the sample; however, the trends were not significant. Out of the 2820 current pregnancies reported, 54.4% were intended, 29.8% were mistimed, 13.2% were unwanted, and 2.5% were ambivalent. After controlling for other predictors, HIV status had no independent effect on mistimed pregnancy but had a significant effect on unwanted pregnancy (RRR = 2.44, 95% CI = 1.65–3.61, p < .001] and ambivalent pregnancy [RRR = 2.07; CI: 1.03 to 4.18, p = 0.041]. In 2004, after the introduction of ART, there was a decreased risk in unintended pregnancy [RR = 0.75; CI: 0.66 to 0.84, p < .001]. Women with a secondary education or higher also had a decreased risk in unintended pregnancy [RR = 0.70; CI: 0.70 to 0.92, p = 0.002]. DISCUSSION: HIV was an important predictor of unwanted pregnancy. Unintended pregnancy decreased in the sample over time which may be due to an increase in ART availability and rising levels of education. BioMed Central 2018-02-27 /pmc/articles/PMC6389071/ /pubmed/29486752 http://dx.doi.org/10.1186/s12905-018-0535-y Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Grilo, Stephanie Ann
Song, Xiaoyu
Lutalo, Tom
Mullinax, Margo
Mathur, Sanyukta
Santelli, John
Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
title Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
title_full Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
title_fullStr Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
title_full_unstemmed Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
title_short Facing HIV infection and unintended pregnancy: Rakai, Uganda, 2001–2013
title_sort facing hiv infection and unintended pregnancy: rakai, uganda, 2001–2013
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389071/
https://www.ncbi.nlm.nih.gov/pubmed/29486752
http://dx.doi.org/10.1186/s12905-018-0535-y
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