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Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
BACKGROUND: Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389118/ https://www.ncbi.nlm.nih.gov/pubmed/28985718 http://dx.doi.org/10.1186/s12881-017-0475-7 |
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author | Diogenes, Tereza Cristina Pinheiro Mourato, Felipe Alves de Lima Filho, José Luiz Mattos, Sandra da Silva |
author_facet | Diogenes, Tereza Cristina Pinheiro Mourato, Felipe Alves de Lima Filho, José Luiz Mattos, Sandra da Silva |
author_sort | Diogenes, Tereza Cristina Pinheiro |
collection | PubMed |
description | BACKGROUND: Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included. RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD. CONCLUSION: CHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12881-017-0475-7) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-6389118 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-63891182019-03-19 Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis Diogenes, Tereza Cristina Pinheiro Mourato, Felipe Alves de Lima Filho, José Luiz Mattos, Sandra da Silva BMC Med Genet Research Article BACKGROUND: Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included. RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD. CONCLUSION: CHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12881-017-0475-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-10-06 /pmc/articles/PMC6389118/ /pubmed/28985718 http://dx.doi.org/10.1186/s12881-017-0475-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Diogenes, Tereza Cristina Pinheiro Mourato, Felipe Alves de Lima Filho, José Luiz Mattos, Sandra da Silva Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis |
title | Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis |
title_full | Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis |
title_fullStr | Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis |
title_full_unstemmed | Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis |
title_short | Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis |
title_sort | gender differences in the prevalence of congenital heart disease in down’s syndrome: a brief meta-analysis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389118/ https://www.ncbi.nlm.nih.gov/pubmed/28985718 http://dx.doi.org/10.1186/s12881-017-0475-7 |
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