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Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis

BACKGROUND: Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence...

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Autores principales: Diogenes, Tereza Cristina Pinheiro, Mourato, Felipe Alves, de Lima Filho, José Luiz, Mattos, Sandra da Silva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389118/
https://www.ncbi.nlm.nih.gov/pubmed/28985718
http://dx.doi.org/10.1186/s12881-017-0475-7
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author Diogenes, Tereza Cristina Pinheiro
Mourato, Felipe Alves
de Lima Filho, José Luiz
Mattos, Sandra da Silva
author_facet Diogenes, Tereza Cristina Pinheiro
Mourato, Felipe Alves
de Lima Filho, José Luiz
Mattos, Sandra da Silva
author_sort Diogenes, Tereza Cristina Pinheiro
collection PubMed
description BACKGROUND: Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included. RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD. CONCLUSION: CHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12881-017-0475-7) contains supplementary material, which is available to authorized users.
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spelling pubmed-63891182019-03-19 Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis Diogenes, Tereza Cristina Pinheiro Mourato, Felipe Alves de Lima Filho, José Luiz Mattos, Sandra da Silva BMC Med Genet Research Article BACKGROUND: Down’s syndrome (DS) affects one per 700 live births and congenital heart disease (CHD) occurs in 40–60% of these patients. Contributing factors to the association between DS and CHD are being unraveled. Gender could be one of them. METHODS: We performed a meta-analysis of CHD prevalence in DS, separated by gender. Three search engines were used and 578 articles were reviewed. Twelve articles were included. RESULTS: Quantitative analysis showed a higher prevalence of CHD, particularly atrioventricular septal defects (AVSD), in female patients. No differences were found in others forms of CHD. CONCLUSION: CHD, particularly AVSD, are more common in the female gender of Down’s syndrome patients. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12881-017-0475-7) contains supplementary material, which is available to authorized users. BioMed Central 2017-10-06 /pmc/articles/PMC6389118/ /pubmed/28985718 http://dx.doi.org/10.1186/s12881-017-0475-7 Text en © The Author(s). 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Diogenes, Tereza Cristina Pinheiro
Mourato, Felipe Alves
de Lima Filho, José Luiz
Mattos, Sandra da Silva
Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
title Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
title_full Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
title_fullStr Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
title_full_unstemmed Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
title_short Gender differences in the prevalence of congenital heart disease in Down’s syndrome: a brief meta-analysis
title_sort gender differences in the prevalence of congenital heart disease in down’s syndrome: a brief meta-analysis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389118/
https://www.ncbi.nlm.nih.gov/pubmed/28985718
http://dx.doi.org/10.1186/s12881-017-0475-7
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