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Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties

Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a tr...

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Detalles Bibliográficos
Autores principales: Bierbaumer, Lisa, Schwarze, Uwe Yacine, Gruber, Reinhard, Neuhaus, Winfried
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389128/
https://www.ncbi.nlm.nih.gov/pubmed/30252599
http://dx.doi.org/10.1080/21688370.2018.1479568
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author Bierbaumer, Lisa
Schwarze, Uwe Yacine
Gruber, Reinhard
Neuhaus, Winfried
author_facet Bierbaumer, Lisa
Schwarze, Uwe Yacine
Gruber, Reinhard
Neuhaus, Winfried
author_sort Bierbaumer, Lisa
collection PubMed
description Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties.
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spelling pubmed-63891282019-02-27 Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties Bierbaumer, Lisa Schwarze, Uwe Yacine Gruber, Reinhard Neuhaus, Winfried Tissue Barriers Reviews Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties. Taylor & Francis 2018-09-25 /pmc/articles/PMC6389128/ /pubmed/30252599 http://dx.doi.org/10.1080/21688370.2018.1479568 Text en © 2018 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.
spellingShingle Reviews
Bierbaumer, Lisa
Schwarze, Uwe Yacine
Gruber, Reinhard
Neuhaus, Winfried
Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
title Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
title_full Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
title_fullStr Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
title_full_unstemmed Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
title_short Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
title_sort cell culture models of oral mucosal barriers: a review with a focus on applications, culture conditions and barrier properties
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389128/
https://www.ncbi.nlm.nih.gov/pubmed/30252599
http://dx.doi.org/10.1080/21688370.2018.1479568
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