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Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties
Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a tr...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389128/ https://www.ncbi.nlm.nih.gov/pubmed/30252599 http://dx.doi.org/10.1080/21688370.2018.1479568 |
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author | Bierbaumer, Lisa Schwarze, Uwe Yacine Gruber, Reinhard Neuhaus, Winfried |
author_facet | Bierbaumer, Lisa Schwarze, Uwe Yacine Gruber, Reinhard Neuhaus, Winfried |
author_sort | Bierbaumer, Lisa |
collection | PubMed |
description | Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties. |
format | Online Article Text |
id | pubmed-6389128 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-63891282019-02-27 Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties Bierbaumer, Lisa Schwarze, Uwe Yacine Gruber, Reinhard Neuhaus, Winfried Tissue Barriers Reviews Understanding the function of oral mucosal epithelial barriers is essential for a plethora of research fields such as tumor biology, inflammation and infection diseases, microbiomics, pharmacology, drug delivery, dental and biomarker research. The barrier properties are comprised by a physical, a transport and a metabolic barrier, and all these barrier components play pivotal roles in the communication between saliva and blood. The sum of all epithelia of the oral cavity and salivary glands is defined as the blood-saliva barrier. The functionality of the barrier is regulated by its microenvironment and often altered during diseases. A huge array of cell culture models have been developed to mimic specific parts of the blood-saliva barrier, but no ultimate standard in vitro models have been established. This review provides a comprehensive overview about developed in vitro models of oral mucosal barriers, their applications, various cultivation protocols and corresponding barrier properties. Taylor & Francis 2018-09-25 /pmc/articles/PMC6389128/ /pubmed/30252599 http://dx.doi.org/10.1080/21688370.2018.1479568 Text en © 2018 The Author(s). Published with license by Taylor & Francis. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way. |
spellingShingle | Reviews Bierbaumer, Lisa Schwarze, Uwe Yacine Gruber, Reinhard Neuhaus, Winfried Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties |
title | Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties |
title_full | Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties |
title_fullStr | Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties |
title_full_unstemmed | Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties |
title_short | Cell culture models of oral mucosal barriers: A review with a focus on applications, culture conditions and barrier properties |
title_sort | cell culture models of oral mucosal barriers: a review with a focus on applications, culture conditions and barrier properties |
topic | Reviews |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389128/ https://www.ncbi.nlm.nih.gov/pubmed/30252599 http://dx.doi.org/10.1080/21688370.2018.1479568 |
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