The curse of angiopoietin-2 in ARDS: on stranger TI(E)des

Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment. Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregu...

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Detalles Bibliográficos
Autores principales: Kümpers, Philipp, Lukasz, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Viewpoint
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389145/
https://www.ncbi.nlm.nih.gov/pubmed/29477144
http://dx.doi.org/10.1186/s13054-018-1978-0
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author Kümpers, Philipp
Lukasz, Alexander
author_facet Kümpers, Philipp
Lukasz, Alexander
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collection PubMed
description Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment. Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins. This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability.
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spelling pubmed-63891452019-03-19 The curse of angiopoietin-2 in ARDS: on stranger TI(E)des Kümpers, Philipp Lukasz, Alexander Crit Care Viewpoint Pulmonary inflammation and vascular leakage are hallmarks of acute respiratory distress syndrome (ARDS), a life-threatening condition, for which there is no specific pharmacologic treatment. Recent literature suggests that leaky vessels in pulmonary infection and ARDS may be mediated through dysregulation of a non-redundant endothelial control pathway, the Tie2 receptor and its ligands, the angiopoietins. This Viewpoint summarizes results from cell-based experiments, animal models and clinical studies underlining the potential of Tie2 targeted interventions in reducing infection-mediated pulmonary hyperpermeability. BioMed Central 2018-02-25 /pmc/articles/PMC6389145/ /pubmed/29477144 http://dx.doi.org/10.1186/s13054-018-1978-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Viewpoint
Kümpers, Philipp
Lukasz, Alexander
The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
title The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
title_full The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
title_fullStr The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
title_full_unstemmed The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
title_short The curse of angiopoietin-2 in ARDS: on stranger TI(E)des
title_sort curse of angiopoietin-2 in ards: on stranger ti(e)des
topic Viewpoint
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389145/
https://www.ncbi.nlm.nih.gov/pubmed/29477144
http://dx.doi.org/10.1186/s13054-018-1978-0
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