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Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study

BACKGROUND: Psychotropic medications have been associated with many adverse outcomes in older people living in residential care. Home-like models of residential care may be preferable to traditional models of care and we hypothesized that this model may impact on the prevalence of psychotropic medic...

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Autores principales: Harrison, Stephanie L., Bradley, Clare, Milte, Rachel, Liu, Enwu, Kouladjian O’Donnell, Lisa, Hilmer, Sarah N., Crotty, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389148/
https://www.ncbi.nlm.nih.gov/pubmed/29478410
http://dx.doi.org/10.1186/s12877-018-0752-0
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author Harrison, Stephanie L.
Bradley, Clare
Milte, Rachel
Liu, Enwu
Kouladjian O’Donnell, Lisa
Hilmer, Sarah N.
Crotty, Maria
author_facet Harrison, Stephanie L.
Bradley, Clare
Milte, Rachel
Liu, Enwu
Kouladjian O’Donnell, Lisa
Hilmer, Sarah N.
Crotty, Maria
author_sort Harrison, Stephanie L.
collection PubMed
description BACKGROUND: Psychotropic medications have been associated with many adverse outcomes in older people living in residential care. Home-like models of residential care may be preferable to traditional models of care and we hypothesized that this model may impact on the prevalence of psychotropic medications. The objectives were to: 1) examine associations between psychotropic medications and quality of life in older adults living in residential care facilities with a high prevalence of cognitive impairment and dementia and 2) determine if there was a difference in prevalence of psychotropic medications in facilities which provide a small group home-like model of residential care compared to a ‘standard model’ of care. METHODS: Participants included 541 residents from 17 residential aged care facilities in the Investigating Services Provided in the Residential Environment for Dementia (INSPIRED) study. Cross-sectional analyses were completed to examine the above objectives. Quality of life was measured with the dementia quality of life questionnaire (DEMQOL) and the EQ-5D-5L completed by the resident or a proxy. RESULTS: Overall, 70.8% (n = 380) of the population had been prescribed/dispensed at least one psychotropic medication in the 100 days prior to recruitment. An increased number of psychotropic medications was associated with lower quality of life according to DEMQOL-Proxy-Utility scores (β (SE): − 0.012 (0.006), p = 0.04) and EQ-5D-5L scores (− 0.024 (0.011), p = 0.03) after adjustment for resident-level and facility-level characteristics. Analysis of the individual classes of psychotropic medications showed antipsychotics were associated with lower DEMQOL-Proxy-Utility scores (− 0.030 (0.014), p = 0.03) and benzodiazepines were associated with lower EQ-5D-5L scores (− 0.059 (0.024), p = 0.01). Participants residing in facilities which had a home-like model of residential care were less likely to be prescribed psychotropic medications (OR (95% CI): 0.24 (0.12, 0.46), p < 0.001). CONCLUSIONS: An increased number of psychotropic medications were associated with lower quality of life scores. These medications have many associated adverse effects and the use of these medications should be re-examined when investigating approaches to improve quality of life for older people in residential care. Home-like models of residential care may help to reduce the need for psychotropic medications, but further research is needed to validate these findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0752-0) contains supplementary material, which is available to authorized users.
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spelling pubmed-63891482019-03-19 Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study Harrison, Stephanie L. Bradley, Clare Milte, Rachel Liu, Enwu Kouladjian O’Donnell, Lisa Hilmer, Sarah N. Crotty, Maria BMC Geriatr Research Article BACKGROUND: Psychotropic medications have been associated with many adverse outcomes in older people living in residential care. Home-like models of residential care may be preferable to traditional models of care and we hypothesized that this model may impact on the prevalence of psychotropic medications. The objectives were to: 1) examine associations between psychotropic medications and quality of life in older adults living in residential care facilities with a high prevalence of cognitive impairment and dementia and 2) determine if there was a difference in prevalence of psychotropic medications in facilities which provide a small group home-like model of residential care compared to a ‘standard model’ of care. METHODS: Participants included 541 residents from 17 residential aged care facilities in the Investigating Services Provided in the Residential Environment for Dementia (INSPIRED) study. Cross-sectional analyses were completed to examine the above objectives. Quality of life was measured with the dementia quality of life questionnaire (DEMQOL) and the EQ-5D-5L completed by the resident or a proxy. RESULTS: Overall, 70.8% (n = 380) of the population had been prescribed/dispensed at least one psychotropic medication in the 100 days prior to recruitment. An increased number of psychotropic medications was associated with lower quality of life according to DEMQOL-Proxy-Utility scores (β (SE): − 0.012 (0.006), p = 0.04) and EQ-5D-5L scores (− 0.024 (0.011), p = 0.03) after adjustment for resident-level and facility-level characteristics. Analysis of the individual classes of psychotropic medications showed antipsychotics were associated with lower DEMQOL-Proxy-Utility scores (− 0.030 (0.014), p = 0.03) and benzodiazepines were associated with lower EQ-5D-5L scores (− 0.059 (0.024), p = 0.01). Participants residing in facilities which had a home-like model of residential care were less likely to be prescribed psychotropic medications (OR (95% CI): 0.24 (0.12, 0.46), p < 0.001). CONCLUSIONS: An increased number of psychotropic medications were associated with lower quality of life scores. These medications have many associated adverse effects and the use of these medications should be re-examined when investigating approaches to improve quality of life for older people in residential care. Home-like models of residential care may help to reduce the need for psychotropic medications, but further research is needed to validate these findings. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1186/s12877-018-0752-0) contains supplementary material, which is available to authorized users. BioMed Central 2018-02-26 /pmc/articles/PMC6389148/ /pubmed/29478410 http://dx.doi.org/10.1186/s12877-018-0752-0 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Harrison, Stephanie L.
Bradley, Clare
Milte, Rachel
Liu, Enwu
Kouladjian O’Donnell, Lisa
Hilmer, Sarah N.
Crotty, Maria
Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
title Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
title_full Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
title_fullStr Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
title_full_unstemmed Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
title_short Psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
title_sort psychotropic medications in older people in residential care facilities and associations with quality of life: a cross-sectional study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389148/
https://www.ncbi.nlm.nih.gov/pubmed/29478410
http://dx.doi.org/10.1186/s12877-018-0752-0
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