Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain

We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20–29 days post-inoculation (dpi),...

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Autores principales: Annamalai, Thavamathi, Lin, Chun-Ming, Gao, Xiang, Liu, Xinsheng, Lu, Zhongyan, Saif, Linda J., Wang, Qiuhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389210/
https://www.ncbi.nlm.nih.gov/pubmed/28985754
http://dx.doi.org/10.1186/s13567-017-0469-7
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author Annamalai, Thavamathi
Lin, Chun-Ming
Gao, Xiang
Liu, Xinsheng
Lu, Zhongyan
Saif, Linda J.
Wang, Qiuhong
author_facet Annamalai, Thavamathi
Lin, Chun-Ming
Gao, Xiang
Liu, Xinsheng
Lu, Zhongyan
Saif, Linda J.
Wang, Qiuhong
author_sort Annamalai, Thavamathi
collection PubMed
description We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20–29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively. S-INDEL induced partial protective immunity against the original US PEDV strain.
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spelling pubmed-63892102019-03-19 Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain Annamalai, Thavamathi Lin, Chun-Ming Gao, Xiang Liu, Xinsheng Lu, Zhongyan Saif, Linda J. Wang, Qiuhong Vet Res Short Report We investigated cross-protective immunity of a US spike-insertion deletion porcine epidemic diarrhea virus (PEDV) Iowa106 (S-INDEL) strain against the original US PEDV (PC21A) strain in nursing piglets. Piglets were inoculated orally with S-INDEL, PC21A or mock. At 20–29 days post-inoculation (dpi), all pigs were challenged with the PC21A strain. The S-INDEL-inoculated pigs had lower ileal IgA antibody secreting cells, serum IgA and neutralizing antibody titers compared with PC21A-inoculated pigs. No pigs in the PC21A-group developed diarrhea, whereas 81 and 100% of pigs in the S-INDEL and mock-groups had diarrhea post challenge, respectively. S-INDEL induced partial protective immunity against the original US PEDV strain. BioMed Central 2017-10-06 2017 /pmc/articles/PMC6389210/ /pubmed/28985754 http://dx.doi.org/10.1186/s13567-017-0469-7 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Short Report
Annamalai, Thavamathi
Lin, Chun-Ming
Gao, Xiang
Liu, Xinsheng
Lu, Zhongyan
Saif, Linda J.
Wang, Qiuhong
Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
title Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
title_full Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
title_fullStr Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
title_full_unstemmed Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
title_short Cross protective immune responses in nursing piglets infected with a US spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original US PEDV strain
title_sort cross protective immune responses in nursing piglets infected with a us spike-insertion deletion porcine epidemic diarrhea virus strain and challenged with an original us pedv strain
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389210/
https://www.ncbi.nlm.nih.gov/pubmed/28985754
http://dx.doi.org/10.1186/s13567-017-0469-7
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