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Heterologous expression and antitumor activity analysis of syringolin from Pseudomonas syringae pv. syringae B728a

BACKGROUND: Syringolin, synthesized by a mixed non-ribosomal peptide synthetase/polyketide synthetase in Pseudomonas syringae pv. syringae (Pss) B728a, is a novel eukaryotic proteasome inhibitor. Meanwhile, directly modifying large fragments in the PKS/NRPS gene cluster through traditional DNA engin...

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Detalles Bibliográficos
Autores principales:	Huang, Fan, Tang, Jianli, He, Lian, Ding, Xuezhi, Huang, Shaoya, Zhang, Youming, Sun, Yunjun, Xia, Liqiu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389232/ https://www.ncbi.nlm.nih.gov/pubmed/29482589 http://dx.doi.org/10.1186/s12934-018-0859-1

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