Overriding FUS autoregulation in mice triggers gain-of-toxic dysfunctions in RNA metabolism and autophagy-lysosome axis

Mutations in coding and non-coding regions of FUS cause amyotrophic lateral sclerosis (ALS). The latter mutations may exert toxicity by increasing FUS accumulation. We show here that broad expression within the nervous system of wild-type or either of two ALS-linked mutants of human FUS in mice prod...

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Detalles Bibliográficos
Autores principales: Ling, Shuo-Chien, Dastidar, Somasish Ghosh, Tokunaga, Seiya, Ho, Wan Yun, Lim, Kenneth, Ilieva, Hristelina, Parone, Philippe A, Tyan, Sheue-Houy, Tse, Tsemay M, Chang, Jer-Cherng, Platoshyn, Oleksandr, Bui, Ngoc B, Bui, Anh, Vetto, Anne, Sun, Shuying, McAlonis-Downes, Melissa, Han, Joo Seok, Swing, Debbie, Kapeli, Katannya, Yeo, Gene W, Tessarollo, Lino, Marsala, Martin, Shaw, Christopher E, Tucker-Kellogg, Greg, La Spada, Albert R, Lagier-Tourenne, Clotilde, Da Cruz, Sandrine, Cleveland, Don W
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389288/
https://www.ncbi.nlm.nih.gov/pubmed/30747709
http://dx.doi.org/10.7554/eLife.40811

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