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Blood‐Based Biomarkers of Quinpirole Pharmacology: Cluster‐Based PK/PD and Metabolomics to Unravel the Underlying Dynamics in Rat Plasma and Brain

A key challenge in the development of central nervous system drugs is the availability of drug target specific blood‐based biomarkers. As a new approach, we applied cluster‐based pharmacokinetic/pharmacodynamic (PK/PD) analysis in brain extracellular fluid (brain(ECF)) and plasma simultaneously afte...

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Detalles Bibliográficos
Autores principales:	van den Brink, Willem J., Hartman, Robin, van den Berg, Dirk‐Jan, Flik, Gunnar, Gonzalez‐Amoros, Belén, Koopman, Nanda, Elassais‐Schaap, Jeroen, van der Graaf, Piet Hein, Hankemeier, Thomas, de Lange, Elizabeth C.M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389346/ https://www.ncbi.nlm.nih.gov/pubmed/30680960 http://dx.doi.org/10.1002/psp4.12370

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